ArticleJournal of oral microbiology2025
Longitudinal analysis of oral microbiome changes during the neonatal period in full-term and preterm newborns.
Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- From early prevention to invasive treatment: dental care utilization and outcomes according to gestational age in preterm children.BMC oral health · 2026Observational
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Authors and funding
7 authors.
Funding
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Abstract
Background: The neonatal period is critical for oral microbiome establishment, but temporal patterns in preterm newborns remain unclear. This study examined longitudinal microbiome changes in full-term and preterm newborns and assessed perinatal and clinical influences. Methods: Oral swabs were collected from 98 newborns (23 full-term, 75 preterm). Samples were obtained at birth and Day 2 for full-term, and at birth, Day 7, and Day 28 for preterm newborns. 16S rRNA gene sequencing was used to analyze microbial diversity, taxonomic shifts, and virulence-related genes. Results: Preterm newborns showed persistently lower α-diversity and delayed succession compared with full-term newborns. Full-term infants transitioned rapidly from Proteobacteria-dominant to Firmicutes- and Actinobacteria-rich communities, while preterm infants maintained Proteobacteria longer. Diversity in preterm newborns was significantly affected by gestational age, birthweight, delivery mode, feeding type, and β-lactam exposure. Breastfeeding supported more stable diversity, whereas cesarean delivery and formula feeding reduced diversity. Functional profiling revealed greater abundance of virulence-associated genes in preterm newborns, suggesting differences in early host-microbe interactions. . Conclusions: Preterm newborns exhibit delayed oral microbiome development, influenced by multiple modifiable factors. Supportive strategies, such as breastfeeding and prudent antibiotic use, may help foster microbial stability and potentially reduce infection risk in this vulnerable population.
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