ArticleJournal of hepatocellular carcinoma2025
Newly Established Anoikis-Associated Genes Predict the Prognosis of Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Objective: Anoikis is an anchorage-dependent programmed cell death implicated in multiple pathological processes of cancers; however, the prognostic value of anoikis-related genes (ANRGs) in hepatocellular carcinoma (HCC) remains unclear. Our study aims to develop an ANRGs-based prediction model to improve prognostic assessment in HCC patients. Methods: The RNA-seq profile was performed to estimate the expression of ANRGs in HCC patients. The univariate Cox regression and the least absolute shrinkage and selection operator (LASSO) Cox regression analysis were applied in the model construction to predict the prognosis in terms of differentially expressed ANRGs in the Cancer Genome Atlas (TCGA) training cohort. The TCGA test cohort and the International Cancer Genome Consortium (ICGC)-originated cohort were set to verify the predictive capacity. Nomogram was built on the basis of risk score (RS), gender, age, grade, and T_stage, with the hope of extending the predictive ability of ANRGs to evaluate the HCC prognosis. The expression of differentially expressed ANRGs was assessed in HCC cell lines and orthotopic tumor-bearing mice. Results: Six ANRGs ( Conclusion: Despite the lack of mechanistic validation, our anoikis-linked
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