Evidence map›Paper›PMID 40927554›Full record

ArticleMedComm2025

AI Algorithm for Lung Adenocarcinoma Pattern Quantification (PATQUANT): International Validation and Advanced Risk Stratification Superior to Conventional Grading.

Yuan Wang, Kris Lami, Waleed Ahmad, Simon Schallenberg, Andrey Bychkov, Yuanzi Ye, Danny Jonigk, Xiaoya Zhu, Sofia Campelos, Anne Schultheis and 7 more

Abstract read
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuan WangInstitute of Pathology University Hospital Cologne Cologne Germany.
Kris LamiDepartment of Pathology Informatics Nagasaki University Nagasaki Japan.
Waleed AhmadInstitute of Pathology University Hospital Cologne Cologne Germany.
Simon SchallenbergInstitute of Pathology Charité Berlin Germany.
Andrey BychkovDepartment of Pathology Informatics Nagasaki University Nagasaki Japan.
Yuanzi YeDepartment of Pathology The First Affiliated Hospital of Anhui Medical University Hefei China.
Danny JonigkInstitute of Pathology University Hospital Aachen Aachen Germany.
Xiaoya ZhuDepartment of Pathology of Run Run Shaw Hospital Affiliated to Zhejiang University Hangzhou China.
Sofia CampelosIMP Diagnostics Porto Portugal.
Anne SchultheisInstitute of Pathology University Hospital Freiburg Freiburg Germany.
Matthias HeldweinDepartment of Cardiothoracic Surgery University Hospital Cologne Cologne Germany.
Alexander QuaasInstitute of Pathology University Hospital Cologne Cologne Germany.
Ales RyskaThe Fingerland Department of Pathology Charles University Medical Faculty Hospital Hradec Králové Czech Republic.
Andre L MoreiraDepartment of Pathology NYU Grossman School of Medicine New York New York USA.
Junya FukuokaDepartment of Pathology Informatics Nagasaki University Nagasaki Japan.
Reinhard BüttnerInstitute of Pathology University Hospital Cologne Cologne Germany.
Yuri TolkachInstitute of Pathology University Hospital Cologne Cologne Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphological patterns of lung adenocarcinoma (LUAD) are recognized for their prognostic significance, with ongoing debate regarding the optimal grading strategy. This study aimed to develop a clinical-grade, fully quantitative, and automated tool for pattern classification/quantification (PATQUANT), to evaluate existing grading strategies, and determine the optimal grading system. PATQUANT was trained on a high-quality dataset, manually annotated by expert pathologists. Several independent test datasets and 13 expert pathologists were involved in validation. Five large, multinational cohorts of resectable LUAD (patient

Indexed as

AIgradinglung adenocarcinomalung cancerPATQUANTpattern

Identifiers

PMID40927554
PMCPMC12415442

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.