Evidence map›Paper›PMID 40927550›Full record

ArticleERJ open research2025

The utility of spirometry and single breath gas transfer measurements to identify low total lung capacity.

Ben Knox-Brown, Chara Alexiou, Sanja Stanojevic, Karl P Sylvester

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Pulmonary function test parameters before liver transplantation predict post-transplant survival and respiratory-related death.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
  2. Article
  3. Restriction with Normal Spirometry: A Retrospective Cohort Study.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ben Knox-BrownCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0001-5573-4413
Chara AlexiouCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sanja StanojevicDalhousie University, Halifax, Canada.ORCID https://orcid.org/0000-0001-7931-8051
Karl P SylvesterCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0001-6851-1219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Measurement of total lung capacity (TLC) requires large and expensive equipment. We aimed to investigate whether spirometric restriction and low alveolar volume measured by single breath gas transfer ( Methods: We retrospectively analysed data from adults referred to Cambridge University Hospitals between January 2016 and December 2023. We investigated the utility of spirometric restriction (forced vital capacity (FVC) < lower limit of normal (LLN) with forced expiratory volume in 1 s /FVC ≥LLN) and reduced Results: Data from 7923 patients were included. The majority (94%) of patients were of European ancestry, 51% were female. Mean age was 58 years. 11% of patients had a TLC Conclusions: A FVC in the healthy range is an effective tool for ruling out restriction. Low

Identifiers

PMID40927550
PMCPMC12415716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.