Evidence map›Paper›PMID 40927507›Full record

ArticleJournal of surgical case reports2025

A rare case of hepatoid adenocarcinoma of the lung initially presenting as a painful skin nodule.

Reem Khabbaza, Ayat Shawish, Alaa Mahmoud, Mohammad Adib Houreih, Moatasem Hussein Al-Janabi, Fouz Hassan

Abstract readCase Reports
In one paragraph

Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Hepatoid adenocarcinoma of the lung: clinicopathologic and molecular analysis of 17 cases.Virchows Archiv : an international journal of pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Reem KhabbazaDepartment of Dermatology and Sexually Transmitted Disease, Tishreen University Hospital, Lattakia 041, Syria.
Ayat ShawishDepartment of Dermatology and Sexually Transmitted Disease, Tishreen University Hospital, Lattakia 041, Syria.
Alaa MahmoudDepartment of Dermatology and Sexually Transmitted Disease, Tishreen University Hospital, Lattakia 041, Syria.
Mohammad Adib HoureihDepartment of Pathology, Tishreen University Hospital, Lattakia 041, Syria.
Moatasem Hussein Al-JanabiDepartment of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia 041, Syria.ORCID https://orcid.org/0000-0003-1675-4125
Fouz HassanDepartment of Dermatology and Sexually Transmitted Disease, Tishreen University Hospital, Lattakia 041, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of pulmonary adenocarcinoma, with cutaneous metastasis being an uncommon clinical manifestation. A 49-year-old male presented with a painful, nodular skin lesion on the upper back. Histopathological examination confirmed it as a cutaneous metastasis of HAL. Subsequent imaging revealed a large primary tumor in the left lung and widespread metastatic disease. Remarkably, the skin lesion was the initial and only presenting feature. This case illustrates the variable clinical presentation of HAL and underscores the need for thorough evaluation of atypical skin lesions.

Indexed as

cutaneous metastasishepatoid adenocarcinomaHepPar-1pulmonary hepatoid carcinoma

Identifiers

PMID40927507
PMCPMC12416816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.