Evidence map›Paper›PMID 40927375›Full record

ArticleFrontiers in cellular and infection microbiology2025

Expression of metabolic genes in NK cells is associated with clinical outcomes in patients with severe COVID-19: a brief report.

Kenia Y Osuna-Espinoza, Manuel G Mejia-Torres, Adrian Camacho-Ortiz, Eduardo Perez-Alba, Azalia M Martinez-Castilla, Mario C Salinas-Carmona, Adrian G Rosas-Taraco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenia Y Osuna-EspinozaUniversidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.
Manuel G Mejia-TorresUniversidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.
Adrian Camacho-OrtizUniversidad Autónoma de Nuevo León, Servicio de Infectología, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, NL, Mexico.
Eduardo Perez-AlbaUniversidad Autónoma de Nuevo León, Servicio de Infectología, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, NL, Mexico.
Azalia M Martinez-CastillaUniversidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.
Mario C Salinas-CarmonaUniversidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.
Adrian G Rosas-TaracoUniversidad Autónoma de Nuevo León, Servicio y Departamento de Inmunología, Facultad de Medicina, Monterrey, NL, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are innate lymphocytes with cytotoxic activity against tumors and viruses. The pandemic of the coronavirus disease 2019 (COVID-19) has increased the investigation of their role in disease severity. However, their functional status and modulators remain controversial. Recent studies highlighted the role of metabolism in immune function, but metabolic changes in NK cells during SARS-CoV-2 infection remain unexplored. This study compares metabolic (

Indexed as

COVID-19Killer Cells, NaturalAdultAgedFemaleGlucose Transporter Type 1GranzymesHumansHypoxia-Inducible Factor 1, alpha SubunitInterferon-gammaMaleMiddle AgedNF-kappa B p50 SubunitSARS-CoV-2Severity of Illness IndexSirtuin 1Glucose Transporter Type 1GranzymesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInterferon-gammaNF-kappa B p50 SubunitNFKB1 protein, humanSIRT1 protein, humanSirtuin 1SLC2A1 protein, humanSOCS1 protein, humanSuppressor of Cytokine Signaling 1 ProteinAMPKGLUT1HIF1AmetabolismNK cellssevere COVID-19SIRT1

Identifiers

PMID40927375
PMCPMC12415030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.