ArticleClinical interventions in aging2025
Risk Factors of Subclinical Left Ventricular Systolic Dysfunction in Older Adults with Type 2 Diabetes and Preserved LVEF.
Article in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus: mediation by myocardial energetic efficiency and resting perfusion.Cardiovascular diabetology · 2026Article
- Association of short-term glycemic variability with subclinical myocardial injury in hospitalized patients with type 2 diabetes: a retrospective cross-sectional study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study evaluates cardiac function in older adults with T2DM and preserved LVEF using two-dimensional speckle-tracking echocardiography to explore the risk factors associated with subclinical left ventricular systolic dysfunction (GLS <18%) in this population. Methods: All patients (n = 87, aged 60 years and above) and controls (n = 20) underwent clinical assessment and echocardiography, including GLS assessment. Results: Univariate analysis identified gender (OR 3.368, p=0.008), proteinuria (OR 5.918, p=0.003), eGFR (OR 0.971, p=0.003), HDL (OR 0.201, p=0.013), triglycerides (OR 3.379, p=0.005), and HOMA-IR (OR 1.173, p=0.049) as potential risk factors for subclinical LV systolic insufficiency in older T2DM patients with preserved LVEF. Following adjustment for age and clinical covariates, multivariate logistic regression confirmed proteinuria (OR 4.063, p=0.030), eGFR (OR 0.974, p=0.049), hypertriglyceridemia (OR 3.069, p=0.050), and HOMA-IR (OR 1.249, p=0.026) as independent predictors. Conclusion: Despite normal global LVEF, proteinuria, hypertriglyceridemia, reduced eGFR, and insulin resistance are closely associated with the development of subclinical left ventricular systolic insufficiency in asymptomatic older adults with T2DM. Trial Registration: This study adheres to the principles outlined in the Declaration of Helsinki and received approval from the Ethics Review Committee of Huadong Hospital, affiliated with Fudan University (Approval No. 2022K150). Written informed consent was obtained from all participants. The registration number of this study at the Chinese Clinical Trial Center is ChiCTR2200062070.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.