ArticleFrontiers in medicine2025
Oxygen targets in patients with septic shock: a retrospective cohort study on the association between hyperoxia and mortality.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In critically ill patients with septic shock, adequate oxygenation is crucial and hypoxia should be avoided. However, hyperoxia has been linked to the formation of reactive oxygen species, inflammation, and vasoconstriction, which could potentially harm critically ill intensive care patients. Therefore, this study aimed to examine the association between oxygen exposure and mortality and to define optimal oxygen target ranges for this specific group of patients. Methods: This retrospective, single-center cohort study examined the influence of arterial oxygen partial pressure (PaO Results: A total of 2,647 cases from 2,463 patients, identified between January 2016 and December 2022, met the inclusion criteria. The time-weighted mean PaO Conclusion: In this cohort, the PaO
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