Evidence map›Paper›PMID 40927039›Full record

ArticleWellcome open research2025

Protocol to produce a systematic Arenavirus and Hantavirus host-pathogen database: Project ArHa.

David Simons, Ricardo Rivero, Ana Martinez-Checa Guiote, Harry Luke Mackenzie Gordon, Gregory C Milne, Grant Rickard, David W Redding, Stephanie N Seifert

Abstract read
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David SimonsDepartment of Anthropology, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9655-1656
Ricardo RiveroPaul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA.
Ana Martinez-Checa GuioteScience Department, Natural History Museum, London, England, UK.ORCID https://orcid.org/0009-0003-4263-444X
Harry Luke Mackenzie GordonScience Department, Natural History Museum, London, England, UK.
Gregory C MilneScience Department, Natural History Museum, London, England, UK.
Grant RickardPaul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA.ORCID https://orcid.org/0009-0005-4620-5911
David W ReddingScience Department, Natural History Museum, London, England, UK.
Stephanie N SeifertPaul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA.ORCID https://orcid.org/0000-0002-4397-6156

Funding

Wellcome Trust
6 · The paper itself

Abstract

Arenaviruses and Hantaviruses, primarily hosted by rodents and shrews, represent significant public health threats due to their potential for zoonotic spillover into human populations. Despite their global distribution, the full impact of these viruses on human health remains poorly understood, particularly in regions like Africa, where data is sparse. Both virus families continue to emerge, with pathogen evolution and spillover driven by anthropogenic factors such as land use change, climate change, and biodiversity loss. Recent research highlights the complex interactions between ecological dynamics, host species, and environmental factors in shaping the risk of pathogen transmission and spillover. This underscores the need for integrated ecological and genomic approaches to better understand these zoonotic diseases. A comprehensive, spatially, and temporally explicit dataset, incorporating host-pathogen dynamics and human disease data, is crucial for improving risk assessments, enhancing disease surveillance, and guiding public health interventions. Such a dataset (ArHa) would also support predictive modelling efforts aimed at mitigating future spillover events. This paper proposes the development of this unified database for small-mammal hosts of Arenaviruses and Hantaviruses, identifying gaps in current research and promoting a more comprehensive understanding of pathogen prevalence, spillover risk, and viral evolution.

Indexed as

arenavirusesdatabase production protocolhantavirusespathogen surveillancerodent-borne zoonoses

Identifiers

PMID40927039
PMCPMC12415512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.