Evidence map›Paper›PMID 40926977›Full record

ArticleBrain communications2025

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation.

Ellen Sapp, Adel Boudi, Andrew Iwanowicz, Jillian Belgrad, Rachael Miller, Riannon Robertson, Daniel O'Reilly, Ken Yamada, Yunping Deng, Marion Joni and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Ellen SappDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.ORCID https://orcid.org/0000-0002-0905-4940
Adel BoudiDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Andrew IwanowiczDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Jillian BelgradRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Rachael MillerDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Riannon RobertsonDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Daniel O'ReillyRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Ken YamadaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID https://orcid.org/0000-0002-5714-8298
Yunping DengDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Marion JoniDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Xueyi LiDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Kimberly Kegel-GleasonDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Anastasia KhvorovaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID https://orcid.org/0000-0001-6928-8071
Anton ReinerDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neil AroninDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Marian DiFigliaDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

Funding

Advancing RNA Therapeutics for Huntington’s DiseaseU01NS114098 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ARONIN, NEIL · 2020 to 2024
$6.7M
Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disordersR01NS104022 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANASTASIA KHVOROVA · 2017 to 2026
$6.0M
High-throughput Oligonucleotide Production SystemS10OD036329 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KHVOROVA, ANASTASIA · 2024 to 2024
$1.4M
Mid-Scale RNA Synthesis, Purification and Quality Control SystemS10OD020012 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KHVOROVA, ANASTASIA · 2015 to 2015
$563k
NIH HHS S10 OD020012NIH HHS S10 OD036329NINDS NIH HHS R01 NS104022NINDS NIH HHS U01 NS114098
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HTT1aMSH3 silencingsmearwestern blot

Identifiers

PMID40926977
PMCPMC12416564

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.