ArticleCureus2025
Evaluating Vitamin D Deficiency-Linked Digestive Issues by Bridging Endocrinology With Gastrointestinal Disorders.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundVitamin D insufficiency is increasingly recognized as a significant and underlying contributor to a wide range of musculoskeletal disorders, particularly in gastrointestinal (GI) and endocrine health. The study aims to determine the clinical relationship between vitamin D status and the severity of GI symptoms, while also assessing the impact of related endocrine disturbances.
methodsA cross-sectional study was conducted involving 120 adult patients with GI problems, including constipation, bloating, irritable bowel syndrome (IBS), and dyspepsia in a tertiary care hospital over a six-month duration. Measurement of serum 25-hydroxyvitamin D (25(OH)D), cortisol, and parathyroid hormone (PTH) was obtained. GI signs were documented on validated symptom scales, and correlations were analyzed by Pearson correlation.
resultsAmong 120 participants, 81.7% (98) were vitamin D-deficient with an average serum level of 16.8 ng/mL. Patients with a deficiency had significantly more symptoms of IBS and high values of symptom severity scores. The decreased vitamin D was correlated with severe reflux (r = -0.31, p = 0.009), constipation (r = -0.42, p < 0.001), belly pain (r = -0.37, p = 0.003), gas and bloating (r = -0.34, p = 0.005), and bowel incontinence (r = -0.27, p = 0.018). It was also moderately and negatively correlated (r = -0.29, p = 0.012) with the fatty liver index. Furthermore, 65% of individuals had increased levels of cortisol and PTH.
conclusionVitamin D deficiency is common in patients with chronic GI symptoms and correlates with increased symptom severity and endocrine disruptions. Functional GI disorders can be clinically managed by incorporating vitamin D and hormonal testing into regular diagnostics. Identifying and addressing these factors early may help develop effective and personalized treatment approaches.
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