ArticleFrontiers in cardiovascular medicine2025
Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Epidemiology of Syphilis, Diagnosis, Differential Diagnosis and Treatment: Up-to-Date Knowledge.Journal of clinical medicine · 2026Review
- Article
- Intravascular ultrasound-guided percutaneous coronary intervention for syphilitic coronary ostial lesions: a single-center case series.Frontiers in cardiovascular medicine · 2026Article
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6 authors.
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Abstract
Due to the low incidence of cardiovascular involvement in syphilis, there are currently no established consensus or guidelines for managing such cases. The patient, with no coronary artery disease risk factors, presented with chest pain and heart failure (HF). Emergency coronary angiography revealed severe stenosis of the bilateral coronary ostia, with smooth intimal lining in the remaining coronary arteries. Echocardiography showed severe aortic regurgitation. Positive syphilis serology strongly suggested cardiovascular syphilis (CVS). The patient was transferred to cardiothoracic surgery for aortic valve replacement (AVR) and coronary artery bypass grafting (CABG), but died from acute HF despite resuscitation efforts.
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