Evidence map›Paper›PMID 40926877›Full record

ArticleOpen forum infectious diseases2025

Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?

Xin Niu, Derin Sevenler, Sandy Dossantos, Mehmet Toner, Rebecca Sandlin, Oraphan Siriprakaisil, Pra-Ornsuda Sukrakanchana, Tim R Cressey, Paul K Drain

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In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin NiuDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9136-3434
Derin SevenlerCenter for Engineering in Medicine & Surgery, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Sandy DossantosCenter for Engineering in Medicine & Surgery, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Mehmet TonerCenter for Engineering in Medicine & Surgery, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Rebecca SandlinCenter for Engineering in Medicine & Surgery, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Oraphan SiriprakaisilSanpatong Hospital, Chiang Mai, Thailand.
Pra-Ornsuda SukrakanchanaAMS-PHPT Research Collaboration, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Tim R CresseyAMS-PHPT Research Collaboration, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Paul K DrainDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9569-4097

Funding

A Rapid Point-of-Care Test to Improve ART and PrEP AdherenceR01AI136648 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAIN, PAUL K · 2018 to 2020
$2.3M
A Point-of-Care Assay to Measure Tenofovir for Monitoring PrEP and ART AdherenceR21AI127200 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAIN, PAUL K · 2016 to 2017
$396k
NIAID NIH HHS R01 AI136648NIAID NIH HHS R21 AI127200
6 · The paper itself

Abstract

Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.

Indexed as

adherenceHIVPrEPtenofovirurine

Identifiers

PMID40926877
PMCPMC12415330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.