ArticleAlpha psychiatry2025
The Association Between Obesity and Depressive Symptoms: Mediation by C-Reactive Protein and Neutrophil-to-Lymphocyte Ratio.
Article in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association between relative fat mass and chronic cardiorenal syndrome: A cross-sectional study based on NHANES 1999 to 2018.Medicine · 2026Article
- Clinical implications of admission anemia for electroconvulsive therapy planning in adolescent major depressive disorder: identifying vulnerable subgroups with poorer response.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity and depressive disorders are significant public health concerns, and their association is well-documented. This study investigates the role of inflammatory markers, specifically C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), in mediating the relationship between obesity and depressive symptoms. Methods: We utilized data from 37,538 adults from the National Health and Nutrition Examination Survey (NHANES), covering the period from 2005 to March, 2020, pre-pandemic. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), while inflammatory markers were assessed via NLR and CRP levels. Results: Results indicated a positive correlation between obesity, NLR, and CRP levels, and depressive symptoms. Notably, CRP exhibited a significant mediating effect in the obesity and depressive symptoms link, whereas NLR did not. (NLR: 0.0926%, Conclusion: These findings provide new insights into the mechanisms linking obesity and depressive symptoms, especially in men, and may guide future therapeutic strategies.
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