Evidence map›Paper›PMID 40926681›Full record

ArticleEpigenomics2025

MicroRNAs signatures in small extracellular vesicles for psychological resilience in young adults using machine learning.

Chia-Hsuan Li, Bao-Yu Chen, Chih-Wei Lin, Shulan Hsieh, Cheng-Ta Yang, Joshua Oon Soo Goh, Yun-Hsuan Chang, Sheng-Hsiang Lin

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Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chia-Hsuan LiDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0009-0006-8643-4652
Bao-Yu ChenInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-3444-8829
Chih-Wei LinInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0009-0009-8599-3016
Shulan HsiehDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cheng-Ta YangDepartment of Psychology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Joshua Oon Soo GohDepartment of Psychology, College of Science, National Taiwan University, Taipei, Taiwan.
Yun-Hsuan ChangDepartment of Psychology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Sheng-Hsiang LinInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-2925-5352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPsychological resilience refers to an individual's capacity to adapt to adverse events. MicroRNAs (miRNAs) play a crucial role in regulating post-transcriptional processes, while small extracellular vesicles (sEVs) act as transport vehicles. This study aimed to employ genome-wide profiling to identify and validate differences in the expression of resilience-associated sEV-miRNAs between low resilience (LR) and high resilience (HR) in young adults.

methodsEighty participants were divided into LR or HR based on the Connor - Davidson Resilience Scale (CD-RISC). The expression levels of the target sEV-miRNAs in LR and HR were compared and analyzed.

resultsExpression analyses demonstrated significant differences in let-7b, miR-151b, miR-335, and miR-193a between LR and HR (

conclusionsThese findings suggest that sEV-miRNAs hold potential as biomarkers for psychological resilience in young adults.

Indexed as

Extracellular VesiclesMachine LearningMicroRNAsResilience, PsychologicalAdultFemaleGene Expression ProfilingHumansMaleYoung AdultMicroRNAsepigenetic regulatorsexplainable machine learningmental healthmicroRNAspost-transcriptional regulationPsychological resiliencesmall extracellular vesiclesstress

Identifiers

PMID40926681
PMCPMC12520076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.