ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
Optimization of CEST MRI Reporter Protein Design Using Cation-Pi Networks.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Generation of hTERT-immortalized human mesenchymal stromal cells with optical and magnetic labels for in vivo transplantation and tracking.Stem cell research & therapy · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Nucleic acid-based therapeutics, such as oncolytic virotherapy or gene therapy, would benefit greatly from a reporter gene that induces endogenous production of a protein biomarker to noninvasively track the delivery, persistence, and spread with imaging. Several chemical exchange saturation transfer (CEST) reporter proteins detectable by magnetic resonance imaging (MRI) have been demonstrated to have high sensitivity. However, to date none can provide strong CEST contrast at a distinct resonance from that of endogenous proteins, limiting their specificity. We investigated proteins and peptides containing tyrosine (Tyr), tryptophan (Trp), and lysine (Lys) residues that demonstrate CEST contrast shifted far downfield (4-10 ppm) from water. Although Tyr, Trp, and Lys exchangeable protons are typically not detectable under physiological conditions, those in our tested molecules are, having exchange rates of 400-2500 s
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Registered trials
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