Evidence map›Paper›PMID 40926564›Full record

ArticleDevelopment and psychopathology2025

Pathways of intergenerational transmission of depression: The role of the Fast Track intervention.

Laura Gorla, W Andrew Rothenberg, Jennifer Godwin, William E Copeland, Conduct Problems Prevention Research Group

Registry-linked trialAbstract read
In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01653535 (Multisite Prevention of Conduct Problems), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01653535 naactive not recruitingnot on this map

Multisite Prevention of Conduct Problems

TypeinterventionalSponsorDuke UniversityRan1991 to 2029Enrolled891ConditionsConduct Disorder, Anti-Social BehaviorArmsFast Track
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Review
  2. Intergenerational associations of depression and anxiety among adult mother-daughter dyads in China.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura GorlaCenter for Child and Family Policy, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0001-5939-3134
W Andrew RothenbergCenter for Child and Family Policy, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0002-1739-9041
Jennifer GodwinCenter for Child and Family Policy, Duke University, Durham, NC, USA.
William E CopelandUniversity of Vermont, Burlington, VT, USA.
Conduct Problems Prevention Research Group

Funding

TRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI HOYLE, RICK · 2008 to 2023
$19.6M
Optimizing Prevention of Costly Adult OutcomesR01DA016903 · NIDA · DUKE UNIVERSITY · PI CROWLEY, DANIEL MAX, DODGE, KENNETH A · 2003 to 2019
$10.2M
Vulnerability to Drug Abuse:Pathways to RecoveryR01DA011301 · NIDA · DUKE UNIVERSITY · PI COSTELLO, ELIZABETH JANE · 1997 to 2015
$7.3M
Intervention Impacts on Child Wellbeing and Parenting across GenerationsR01HD093651 · NICHD · DUKE UNIVERSITY · PI KENNETH A DODGE, Jennifer E Lansford · 2017 to 2026
$6.1M
MULTISITE PREVENTION OF CONDUCT PROBLEMSR18MH048043 · NIMH · DUKE UNIVERSITY · PI DODGE, KENNETH A · 1990 to 2002
$5.8M
MULTISITE PREVENTION OF CONDUCT DISORDERSR18MH050951 · NIMH · UNIVERSITY OF WASHINGTON · PI MCMAHON, ROBERT J. · 1993 to 2002
$3.7M
MULTISITE PREVENTION OF CONDUCT DISORDERR18MH050952 · NIMH · VANDERBILT UNIVERSITY · PI PINDERHUGHES, ELLEN E · 1993 to 2002
$3.7M
MULTISITE PREVENTION OF CONDUCT DISORDERR18MH050953 · NIMH · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BIERMAN, KAREN L · 1993 to 2002
$3.5M
ECONOMIC ANALYSIS OF THE FAST TRACK INTERVENTIONR01MH062988 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOSTER, EDWARD MICHAEL · 2002 to 2007
$2.8M
Diseases of Despair in Young Adulthood: Risk, Resilience, and PreventionR01MH117559 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI COPELAND, WILLIAM · 2018 to 2021
$1.6M
Adolescent Drug Use: Development, Prevention, and PolicyK05DA015226 · NIDA · DUKE UNIVERSITY · PI DODGE, KENNETH A · 2002 to 2012
$1.2M
Emergence of Adolescent Substance Use Problems from the Externalizing SpectrumRC1DA028248 · NIDA · UNIVERSITY OF WASHINGTON · PI KING, KEVIN MICHAEL · 2009 to 2010
$857k
NICHD NIH HHS R01 HD093651NIDA NIH HHS K05 DA015226NIDA NIH HHS P30 DA023026NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA016903NIDA NIH HHS R01 DA036523NIDA NIH HHS RC1 DA028248NIMH NIH HHS K05 MH000797NIMH NIH HHS K05 MH001027NIMH NIH HHS R01 MH062988NIMH NIH HHS R01 MH117559NIMH NIH HHS R18 MH048043NIMH NIH HHS R18 MH050951NIMH NIH HHS R18 MH050952NIMH NIH HHS R18 MH050953
6 · The paper itself

Abstract

Although depression can be transmitted across generations, less is known about how this cycle can be interrupted. This study examines whether the multilevel Fast Track intervention (clinicaltrials.gov, NCT01653535) disrupts intergenerational transmission of depression. Children at high risk for aggression were randomly assigned to a 10-year control group or intervention targeting parenting and children's intrapersonal, interpersonal, and academic skills. The original sample included 891 first-generation (G1) participants who reported on their depression and their children's (second-generation; G2) internalizing problems. At age 34, 374 G2 participants (

Indexed as

Depressionintergenerational relationshipsmental healthpreventive interventions

Identifiers

PMID40926564
PMCPMC12486471

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.