Evidence map›Paper›PMID 40926449›Full record

ReviewUltrasonics sonochemistry2025

New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials.

Wei Sang, Haoliang Fan, Yijun Huang, Junfeng Zhang, Weiqi Gao, Chaoran Zhao, Xiaoyao Liu, Linmei Zhao, Yulong Liu, Yunlu Dai and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei SangShanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China; Institute of Medical Technology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China. Electronic address: sangwei@sxmu.edu.cn.
Haoliang FanSchool of Forensic Medicine, Shanxi Medical University, Taiyuan, China.
Yijun HuangThe First Clinical Medical School, Shanxi Medical University, Taiyuan, China.
Junfeng ZhangThe Seventh Clinical Medical College of Shanxi Medical University, Linfen, China.
Weiqi GaoShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Chaoran ZhaoSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Xiaoyao LiuSchool of Public Health, Shanxi Medical University, Taiyuan, China.
Linmei ZhaoThe Seventh Clinical Medical School of Shanxi Medical University, Linfen People's Hospital, Linfen, China. Electronic address: 2594583591@qq.com.
Yulong LiuShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China. Electronic address: yulongliu01@foxmail.com.
Yunlu DaiCancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China. Electronic address: yldai@um.edu.mo.
Ruiping ZhangThe Radiology Department of Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, China. Electronic address: zrp_7142@sxmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.

Indexed as

NanostructuresNeoplasmsUltrasonic TherapyUltrasonic WavesAnimalsHumansCancerDiagnosisNanomaterialTherapyUltrasound

Identifiers

PMID40926449
PMCPMC12454903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.