ArticleCancer medicine2025
Predicting Grade and Patient Survival in Renal Cancer Using Machine Learning Analysis of Nucleolar Prominence.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Predicting Grade and Patient Survival in Renal Cancer Using Machine Learning Analysis of Nucleolar Prominence.Cancer medicine · 2025Article
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17 authors.
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Abstract
backgroundPatients with clear cell renal cell carcinoma (ccRCC) often undergo organ resection, with treatment strategies based on recurrence risk. Current metastatic potential assessments rely on the WHO/ISUP grading system, which is subject to interobserver variability.
methodsWe developed an artificial intelligence (AI) model to classify cells according to contemporary grading rules and evaluated the prognostic significance of tumor cell profiles, particularly focusing on cells with prominent nucleoli.
resultsThe model accurately distinguished low (G1/G2) and high (G3/G4) grades, achieving an area under the ROC curve of 0.79. Survival analysis identified four tissue patterns defined by total cell density and the proportion of cells with prominent nucleoli. The relative abundance of such cells had greater prognostic value than their mere presence, correlating with survival times ranging from 2.2 to over 6 years. Additionally, we confirmed that dystrophic changes and focal necrosis are linked to shorter survival.
conclusionThese findings suggest that incorporating refined criteria into the WHO/ISUP system could enhance its prognostic accuracy in future revisions.
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