ArticleJournal of the American Society for Mass Spectrometry2025
Complementary Separation of Novel Synthetic Opioids.
Article in Journal of the American Society for Mass Spectrometry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
The escalating prevalence and diversity of fentanyl analogues poses an immediate concern for the global community. Fentanyl and its analogues are the primary contributors to both fatal and nonfatal overdoses in the United States. The most recent instances of fentanyl-related overdoses have been attributed to the illicit production of fentanyl, characterized by its exceptionally potent nature. In this study, we present a high-throughput mass spectrometry based method for effective screening of fentanyl analogues with focus on the isomeric separation using commercially available platforms combining liquid chromatography, trapped ion mobility spectrometry, and tandem mass spectrometry (LC-TIMS-q-TOF MS/MS). The proposed analysis allows for effective separation and identification of 250 synthetic opioids based on the isotopic pattern, retention time, mobility profile, and MS/MS pattern. Our approach capitalizes on the advancements incorporating parallel accumulation in the mobility trap followed by sequential fragmentation (PASEF) using collision-induced dissociation on the liquid chromatography time scale. While a single chromatography band is commonly observed for single isomeric analogues, a dual mobility band profile attributed to two protonation sites is commonly observed for most fentanyl analogues. Reference mobility values are reported from single standards with 0.2% RSD collected at high resolution (R
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