ArticleCancer medicine2025
BMI-dependent prognostic role of EEF1G in breast cancer: A 15-year follow-up of the Guangzhou Breast Cancer Cohort Study.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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9 authors.
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Abstract
objectiveEukaryotic elongation factor 1 gamma (EEF1G) has emerged as a potential prognostic marker in various malignancies. Yet, its association with breast cancer (BC) prognosis, particularly in the context of body mass index (BMI) status, remains unexplored. Therefore, we investigated the prognostic value and role of EEF1G in BC across different BMI categories.
methodsEEF1G expression was assessed through immunohistochemistry in tissue microarrays on 1011 patients with primary invasive BC. Prognostic effects were analyzed using the Cox proportional hazards regression. GSE78958 dataset downloaded from the Gene Expression Omnibus (GEO) database was used to validate our findings. Gene Set Enrichment Analysis (GSEA) was performed using R packages, and protein-protein interaction (PPI) networks were generated using the STRING database and Cytoscape software.
resultsElevated EEF1G expression was associated with a better prognosis in patients with BMI ≤ 24 kg/m
conclusionsThis study showed EEF1G expression was inversely associated with BC prognosis in different BMI categories, indicating its potential as a prognostic marker and therapeutic target in BC. The differential effects underscore the need for personalized approaches in BC management and research.
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