ArticleMolecular plant pathology2025
Regulation of Oomycete Autophagy, Lipid Droplet Accumulation and Pathogenesis by Three Rab GTPases.
Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Genome Re-Sequencing and Functional Analysis Reveal an α-1,3-Glucosyltransferase Conferring Metalaxyl Resistance inJournal of fungi (Basel, Switzerland) · 2026Article
- Regulation of Oomycete Autophagy, Lipid Droplet Accumulation and Pathogenesis by Three Rab GTPases.Molecular plant pathology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Among eukaryotes, Rab GTPases are critical for intracellular membrane trafficking and possess various functions. Oomycetes, responsible for many devastating plant diseases, pose a significant threat to global agriculture. However, the functions of Rab GTPases in oomycetes are largely uncharted. In this study, we functionally characterised two Rab8 homologues, PlRab8A and PlRab8B, from a plant-pathogenic oomycete, Peronophythora litchii. These genes are crucial for mycelial growth and play significant roles in the production and morphology of sporangia, as well as the formation of zoospores. PlRab8A and PlRab8B also contribute to maintaining cell wall integrity, osmotic stress tolerance and oospore formation, which are vital for the organism's survival and virulence. Moreover, PlRab8A and PlRab8B are essential for the full virulence of P. litchii by influencing laccase activity. We also found that PlRab8B co-localised with lipid droplets (LDs) and negatively affected LD accumulation. Autophagy was enhanced and autophagy-related genes (PlATGs) were up-regulated in PlRab8B mutants. Additionally, PlRab8A was found to interact with PlRab6. Similar to PlRab8, PlRab6 is also required for growth, zoospore formation and pathogenicity of P. litchii. Taken together, this study reported for the first time the functions of three Rab proteins regulating autophagy, LD accumulation and pathogenesis in oomycetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.