Evidence map›Paper›PMID 40926334›Full record

ArticleAlcohol, clinical & experimental research2025

Latent profile analysis of trait impulsivity facets and associations with resilience, problematic alcohol use, and quality of life.

Heidi H Meyer, Matthew F Thompson, Tommy Gunawan, Melanie L Schwandt, Vijay A Ramchandani, Nancy Diazgranados, Jeremy W Luk

Abstract read
In one paragraph

Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heidi H MeyerOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Matthew F ThompsonDepartment of Psychiatry & Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Tommy GunawanOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-8942-2829
Melanie L SchwandtOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Vijay A RamchandaniHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-2474-2183
Nancy DiazgranadosOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Jeremy W LukOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-9061-1555

Funding

NIAAA Repository/Screening Database Management and ResearchZIAAA000130 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SCHWANDT, MELANIE · 2017 to 2025
$60.1M
Training in Child/Adolescent Biobehavioral HIV ResearchT32MH078788 · NIMH · RHODE ISLAND HOSPITAL · PI LARRY K BROWN · 2007 to 2026
$6.2M
Intramural NIH HHS ZIA AA000130NIAAA NIH HHS Z1A AA000130NIMH NIH HHS T32 MH078788
6 · The paper itself

Abstract

backgroundImpulsivity is a multidimensional construct that is associated with problematic alcohol use and alcohol use disorder (AUD). Modeling within-person clustering of impulsivity facets has the potential to aid clinical case conceptualization, and examining associations with resilience and well-being outcomes can inform strength-based intervention approaches. In this study, we utilized latent profile analysis (LPA) to capture the clustering of trait impulsivity facets and tested resilience as a mediational pathway linking impulsivity latent profiles to problematic alcohol use and quality of life domains.

methodsA total of 401 adults (59.9% male and 71.6% with past-year AUD) who completed self-reported measures of trait impulsivity (Barratt Impulsiveness Scale and UPPS-P Impulsive Behavior Scale), resilience, and alcohol-related outcomes were included in this study. Statistical analyses included LPA, linear regression, and path analysis.

resultsLPA identified three profiles that varied by overall impulsivity as well as specific levels of negative and positive urgency: Profile 1-Low Impulsivity/Urgency (36.4%), Profile 2-Medium Impulsivity (45.6%), and Profile 3-High Impulsivity/Urgency (18.0%). The percentages of past-year AUD were 37.7% in Profile 1, 87.4% in Profile 2, and 100% in Profile 3. Latent profiles with higher impulsivity had lower resilience, higher problematic alcohol use, and lower quality of life. Low resilience was a significant mediator of associations between Medium/High Impulsivity profiles and all clinical outcomes, including problematic alcohol use and four quality of life domains.

conclusionsIn this person-centered analysis, individuals who scored high on negative urgency also had elevated scores on positive urgency and several other impulsivity facets. Within-person clustering of impulsivity facets was associated with differential risk for AUD, and latent profile differences in problematic alcohol use and quality of life outcomes were mediated by low resilience. Findings highlight resilience as a potential treatment target that warrants further evaluation in clinical research.

Indexed as

Alcohol DrinkingAlcoholismImpulsive BehaviorQuality of LifeResilience, PsychologicalAdultFemaleHumansMaleMiddle AgedYoung Adultimpulsivitynegative urgencypositive urgencyquality of liferesilience

Identifiers

PMID40926334
PMCPMC12519064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.