Evidence map›Paper›PMID 40926271›Full record

ArticleJournal of cannabis research2025

Medical cannabis legalization and the use of illicit drugs, alcohol, and tobacco.

Hana Al Hallaj, Zahraa Barakat

Abstract read
In one paragraph

Article in Journal of cannabis research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hana Al HallajTechnische Universität Berlin , Building H, Space H4136A, Straße des 17. Juni 135, Berlin, 10623, Germany. hanahallaj9@gmail.com.ORCID http://orcid.org/0009-0007-7371-9787
Zahraa BarakatDepartment of EconomicsMA in Applied Economics, Lebanese American University, P.O. Box: 13-5053, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAmidst the global shift toward cannabis legalization, this study examines medical cannabis (MC) sales as an indicator of economic activity and innovation. It explores associations between MC sales, and variables including tobacco use, alcohol consumption, amphetamine, cocaine and cannabis prevalence, and gross domestic product (GDP), using a fixed effects (FE) panel regression model. It also evaluates associations between cannabis legalization and MC sales over time using a dynamic Difference-in-Differences (DiD) approach with multiple time periods. 

methodsPanel data from 20 countries, including 14 with legalized medical cannabis and 6 without, are analyzed. The dynamic DiD approach estimates the average association for legalizing countries across multiple time periods, enabling comparisons of post-legalization outcomes with those of non-legalizing countries. RESULTS AND

conclusionsThe findings indicate a strong negative association between tobacco use and MC sales, while cannabis consumption shows a positive association with MC markets. Amphetamine use is negatively associated with MC sales, suggesting substitution dynamics. Legalization is associated with an average annual increase of 26.06 tons of MC sales in legalizing countries. Event study estimates confirm a sustained growth trajectory in MC sales following legalization. A robustness check, which excludes the United States-a major outlier in market size-yields a slightly lower average effect of 20.05 but still supports the persistent market expansion. Given the ecological nature of the design, these results should be interpreted as population-level associations rather than individual-level causal effects. Nonetheless, they highlight the potential economic relevance of cannabis legalization in expanding regulated markets and reshaping consumer behavior. The study contributes to debates on legalization, public health, and economic policy by providing empirical evidence on the associations between legal reforms and market dynamics.

Indexed as

AlcoholAmphetaminesAverage treatment effectDifference in differencesDynamic DiDFixed effect modelInnovationMarijuanaMedical cannabisSalesStaggered adoptionTobacco

Identifiers

PMID40926271
PMCPMC12418649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.