ArticleHealth and quality of life outcomes2025
Health-related quality of life among adults with hypertension with or without anxiety and depression: estimates from a national US data.
Article in Health and quality of life outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Lifestyle Habits and Comorbidities as Determinants of Quality of Life in Coronary Artery Disease: A Single-Center Prospective Study.Journal of clinical medicine · 2026Article
- Identification of Mental Health Disorder Symptoms, Predisposing Factors and their Impact on Quality of Life in Young Hypertensive Patients: A Multicenter Longitudinal Study.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
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2 authors.
Funding
Abstract
backgroundHypertension is a prevalent chronic medical condition that can impact health-related quality of life (HRQoL). While a relationship between mental disorders and hypertension is established, the incremental impact of co-occurring mental disorders on HRQoL in hypertensive individuals has not been well-quantified. This study’s primary objective is to examine this relationship using a nationally representative sample.
methodsA retrospective cross-sectional study design was employed. This research uses data from 2016 to 2021 from the Medical Expenditure Panel Survey (MEPS). The study included adult patients with hypertension diagnosis who were 18 years of age or older. The Veterans RAND 12 Item Health Survey (VR-12©) was used to determine HRQoL. A linear regression model was used to estimate the predictors of HRQoL.
resultsA total of 11,773 adults with hypertension were identified. Among them, 8.0% had depression, 9.8% had anxiety, and 6.1% had both illnesses. Hypertensive patients with anxiety or depression had a significantly lower mean PCS score and MCS score compared to those without these mental illnesses. After adjusting for other variables, the HRQoL of hypertensive patients with depression (MCS: β = -6.398), anxiety (MCS: β = -4.438), and both illnesses (MCS: β = -9.211) was significantly lower than that of individuals without these conditions.
conclusionsDepression and anxiety were significantly associated with reduced HRQoL among adults with hypertension. These findings emphasize the significant mental burden in this population. Given the cross-sectional natural of this study, causal relationships could not be established; therefore, future longitudinal studies are needed to explore the direction and mechanisms of these associations.
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