Evidence map›Paper›PMID 40926251›Full record

ArticleBMC infectious diseases2025

Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county.

Vidar Möller, Jenny Welander, Maud Nilsson, Mai Thi-Huyen Nguyen, Martin Holmbom, Håkan Hanberger, Lennart E Nilsson, Åse Östholm, Björn Berglund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vidar MöllerDepartment of Infectious Diseases in Östergötland, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Jenny WelanderDepartment of Clinical Microbiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Maud NilssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Mai Thi-Huyen NguyenDepartment of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.
Martin HolmbomDepartment of Urology in Östergötland, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Håkan HanbergerDepartment of Infectious Diseases in Östergötland, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Lennart E NilssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Åse ÖstholmDepartment of Infectious Diseases in Östergötland, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. ase.ostholm@liu.se.
Björn BerglundDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. bjorn.berglund@icm.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEscherichia coli ST131 and clade H30Rx are the most prevalent extended-spectrum β-lactamase-producing E. coli (ESBL-EC) causing bacteremia and urinary tract infections globally and in Sweden. Previous studies have linked ST131-H30Rx with septic shock and mortality, as well as prolonged carriage. In our previous study, ST131 constituted 54% of all ESBL-EC bacteremia originating from the urinary tract.

methodUtilizing whole-genome sequencing, we retrospectively compared virulence factors (VFs) and patient outcomes based on medical records among 77 isolates of ESBL-EC from 76 patients with pyelonephritis between 2009 and 2018 in a Swedish county.

resultsThe VFs Ibes and uropathogenic specific protein were associated with ST131 of all clades (p < 0.0001). Serine protease (p < 0.0001) and cnf1 (p = 0.0003) were more common among ST131-H30Rx compared to non-ST131 isolates whereas enterobactin and iss were more common among ST131-H30Rx compared to both other ST131 isolates (p < 0.0001 and p = 0.0007, respectively) and non-ST131 isolates (p < 0.0001). Sepsis within 36 h was less common among patients infected with ST131-H30Rx (p = 0.038).

conclusionsST131-H30Rx isolates carried VFs which were associated with recurrence but not uniformly to sepsis. In this explorative study, our results indicate that the ST131-H30Rx clade are not more prone to cause severe infection than other sequence types, but prone to cause recurrence, in addition to ESBL production which limits treatment options. Further studies are warranted to explore the mechanisms driving the success of ST131-H30Rx isolates in causing recurrent infections and colonization, and to form preventive measures.

Indexed as

Bacteremiabeta-LactamasesEscherichia coli InfectionsUropathogenic Escherichia coliVirulence FactorsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesSwedenUrinary Tract InfectionsWhole Genome Sequencingbeta-LactamasesVirulence FactorsAntimicrobial resistanceEscherichia coliExtended-spectrum β-lactamaseSepsisST131

Identifiers

PMID40926251
PMCPMC12418608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.