Evidence map›Paper›PMID 40926127›Full record

ReviewNature aging2025

The X-Age Project to construct a Chinese aging clock.

Jiaming Li, Mengmeng Jiang, Qiaoran Wang, Zikai Zheng, Jianghua Shen, Jingyi Li, Muzhao Xiong, Yandong Zheng, Xiaoyong Lu, Yusheng Cai and 260 more

Abstract readReview

PubMed Publisher

In one paragraph

Review in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.Nature aging · 2026
Article
Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.Nature aging · 2026
Article
A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2026
Article
Comparative Cochlear-Vestibular Aging Reveals Age-Aligned Mitochondrial Ultrastructural Burden, Mitophagy-Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline.Aging cell · 2026
Article
Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics.Cellular and molecular life sciences : CMLS · 2026
Article
Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases.JACC. Asia · 2026
Review
Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

270 authors.

Jiaming Li *Aging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0003-2712-0064

Mengmeng Jiang *Aging Biomarker Consortium (ABC), Beijing, China.

Qiaoran Wang *Aging Biomarker Consortium (ABC), Beijing, China.

Zikai Zheng *Aging Biomarker Consortium (ABC), Beijing, China.

Jianghua Shen *Aging Biomarker Consortium (ABC), Beijing, China.

Jingyi Li *Aging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0002-3126-7889

Muzhao Xiong *Aging Biomarker Consortium (ABC), Beijing, China.

Yandong Zheng *Aging Biomarker Consortium (ABC), Beijing, China.

Xiaoyong Lu *Aging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0009-0007-6084-7376

Yusheng CaiAging Biomarker Consortium (ABC), Beijing, China.

Yanling FanAging Biomarker Consortium (ABC), Beijing, China.

Lingling GengAging Biomarker Consortium (ABC), Beijing, China.

Qianzhao JiAging Biomarker Consortium (ABC), Beijing, China.

Qianqian PengAging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0002-2018-5706

Shuhui SunAging Biomarker Consortium (ABC), Beijing, China.

Yuanyuan WangAging Biomarker Consortium (ABC), Beijing, China.

Zijuan XinAging Biomarker Consortium (ABC), Beijing, China.

Kaowen YanAging Biomarker Consortium (ABC), Beijing, China.

Yuanhan YangAging Biomarker Consortium (ABC), Beijing, China.

Jun YuAging Biomarker Consortium (ABC), Beijing, China.

Haoteng YanAging Biomarker Consortium (ABC), Beijing, China.

Ding AiAging Biomarker Consortium (ABC), Beijing, China. edin2000cn@163.com.ORCID http://orcid.org/0000-0001-5992-9904

Yongping BaiAging Biomarker Consortium (ABC), Beijing, China. baiyongping@csu.edu.cn.ORCID http://orcid.org/0000-0002-6355-5842

Yan BiAging Biomarker Consortium (ABC), Beijing, China. biyan@nju.edu.cn.ORCID http://orcid.org/0000-0003-3914-7854

Xiu-Wu BianAging Biomarker Consortium (ABC), Beijing, China. bianxiuwu@263.net.ORCID http://orcid.org/0000-0003-4383-0197

Pengcheng BuAging Biomarker Consortium (ABC), Beijing, China. bupc@ibp.ac.cn.ORCID http://orcid.org/0000-0002-3208-0354

Jian-Ping CaiAging Biomarker Consortium (ABC), Beijing, China. caijp61@vip.sina.com.ORCID http://orcid.org/0000-0003-2793-9221

Chun-Mei CaoAging Biomarker Consortium (ABC), Beijing, China. caochunmei@pku.edu.cn.

Feng CaoAging Biomarker Consortium (ABC), Beijing, China. fengcao8828@163.com.

Zhongwei CaoAging Biomarker Consortium (ABC), Beijing, China. zhongweicao@scu.edu.cn.ORCID http://orcid.org/0000-0001-8778-4327

Renjie ChaiAging Biomarker Consortium (ABC), Beijing, China. renjiec@seu.edu.cn.ORCID http://orcid.org/0000-0002-3885-543X

Piu ChanAging Biomarker Consortium (ABC), Beijing, China. pbchan@hotmail.com.

Chang ChenAging Biomarker Consortium (ABC), Beijing, China. changchen@ibp.ac.cn.ORCID http://orcid.org/0000-0003-1008-1062

Cheng-Shui ChenAging Biomarker Consortium (ABC), Beijing, China. chenchengshui@wmu.edu.cn.

Chunying ChenAging Biomarker Consortium (ABC), Beijing, China. chenchy@nanoctr.cn.ORCID http://orcid.org/0000-0002-6027-0315

Di ChenAging Biomarker Consortium (ABC), Beijing, China. di.chen@siat.ac.cn.ORCID http://orcid.org/0000-0002-4258-3457

Hou-Zao ChenAging Biomarker Consortium (ABC), Beijing, China. chenhouzao@ibms.cams.cn.ORCID http://orcid.org/0000-0001-6805-3182

Lin ChenAging Biomarker Consortium (ABC), Beijing, China. linchen70@163.com.ORCID http://orcid.org/0000-0001-7764-9412

Quan ChenAging Biomarker Consortium (ABC), Beijing, China. chenq@nankai.edu.cn.

Xiao ChenAging Biomarker Consortium (ABC), Beijing, China. sirchenxiao@126.com.ORCID http://orcid.org/0000-0003-4517-0508

Xiaochun ChenAging Biomarker Consortium (ABC), Beijing, China. chenxc998@fjmu.edu.cn.ORCID http://orcid.org/0000-0002-2665-4155

Yu ChenAging Biomarker Consortium (ABC), Beijing, China. yu.chen@siat.ac.cn.ORCID http://orcid.org/0000-0002-7569-9472

Zi-Jiang ChenAging Biomarker Consortium (ABC), Beijing, China. chenzijiang@hotmail.com.ORCID http://orcid.org/0000-0001-6637-6631

Weimin CiAging Biomarker Consortium (ABC), Beijing, China. ciwm@foxmail.com.ORCID http://orcid.org/0000-0002-4111-5360

Zhe DaiAging Biomarker Consortium (ABC), Beijing, China. daizhe@znhospital.cn.ORCID http://orcid.org/0000-0003-0321-0225

Qiurong DingAging Biomarker Consortium (ABC), Beijing, China. qrding@sinh.ac.cn.ORCID http://orcid.org/0000-0001-9906-6787

Birong DongAging Biomarker Consortium (ABC), Beijing, China. birongdong123@outlook.com.ORCID http://orcid.org/0000-0002-2601-5855

Jiahong DongAging Biomarker Consortium (ABC), Beijing, China. dongjiahong@tsinghua.edu.cn.

Jian-Gao FanAging Biomarker Consortium (ABC), Beijing, China. fanjiangao@xinhuamed.com.cn.ORCID http://orcid.org/0000-0001-7443-5056

Shiqing FengAging Biomarker Consortium (ABC), Beijing, China. shiqingfeng@sdu.edu.cn.ORCID http://orcid.org/0000-0002-5939-138X

Xin FengAging Biomarker Consortium (ABC), Beijing, China. xin.feng@ia.ac.cn.ORCID http://orcid.org/0000-0001-9506-8486

Yun FengAging Biomarker Consortium (ABC), Beijing, China. fengyun@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-9453-3259

Xiaobing FuAging Biomarker Consortium (ABC), Beijing, China. fuxiaobing@vip.sina.com.

Xiaolong FuAging Biomarker Consortium (ABC), Beijing, China. fuxiaolongshifan@163.com.ORCID http://orcid.org/0000-0002-3884-0916

Feng GaoAging Biomarker Consortium (ABC), Beijing, China. fgao@fmmu.edu.cn.ORCID http://orcid.org/0000-0001-6555-1717

Jiangang GaoAging Biomarker Consortium (ABC), Beijing, China. jggao@sdu.edu.cn.ORCID http://orcid.org/0000-0001-6619-7107

Qiang GaoAging Biomarker Consortium (ABC), Beijing, China. gaoqiang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-6695-9906

Shaorong GaoAging Biomarker Consortium (ABC), Beijing, China. gaoshaorong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-1041-3928

Yonghao GuAging Biomarker Consortium (ABC), Beijing, China. guyh@ustc.edu.cn.ORCID http://orcid.org/0000-0003-2682-2099

Youfei GuanAging Biomarker Consortium (ABC), Beijing, China. guanyf@dmu.edu.cn.ORCID http://orcid.org/0000-0002-5231-0209

Feifan GuoAging Biomarker Consortium (ABC), Beijing, China. ffguo@fudan.edu.cn.

Jing-Dong J HanAging Biomarker Consortium (ABC), Beijing, China. jackie.han@pku.edu.cn.ORCID http://orcid.org/0000-0002-9270-7139

Haiping HaoAging Biomarker Consortium (ABC), Beijing, China. Haipinghao@cpu.edu.cn.ORCID http://orcid.org/0000-0003-2522-7546

Jihui HaoAging Biomarker Consortium (ABC), Beijing, China. haojihui@tjmuch.com.ORCID http://orcid.org/0000-0002-1607-1730

Fuchu HeAging Biomarker Consortium (ABC), Beijing, China. hefc@bmi.ac.cn.ORCID http://orcid.org/0000-0002-8571-2351

Jinhan HeAging Biomarker Consortium (ABC), Beijing, China. jinhanhe@scu.edu.cn.ORCID http://orcid.org/0000-0001-6487-4696

Ming HeAging Biomarker Consortium (ABC), Beijing, China. heming@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-2086-8312

Mingguang HeAging Biomarker Consortium (ABC), Beijing, China. mingguang_he@yahoo.com.ORCID http://orcid.org/0000-0002-6912-2810

Qiyang HeAging Biomarker Consortium (ABC), Beijing, China. qiyang_he@vip.163.com.ORCID http://orcid.org/0000-0003-3694-6036

Zhiying HeAging Biomarker Consortium (ABC), Beijing, China. zyhe@tongji.edu.cn.ORCID http://orcid.org/0000-0002-0087-2277

Zuhong HeAging Biomarker Consortium (ABC), Beijing, China. hezuhong@163.com.ORCID http://orcid.org/0000-0001-6409-4366

Huashan HongAging Biomarker Consortium (ABC), Beijing, China. 15959159898@163.com.ORCID http://orcid.org/0000-0001-8332-0066

Jiaxu HongAging Biomarker Consortium (ABC), Beijing, China. jiaxu.hong@fdeent.org.ORCID http://orcid.org/0000-0001-9912-633X

Shengping HouAging Biomarker Consortium (ABC), Beijing, China. sphou828@163.com.ORCID http://orcid.org/0000-0002-7796-8891

Cheng HuAging Biomarker Consortium (ABC), Beijing, China. alfredhc@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-4314-2386

Ping HuAging Biomarker Consortium (ABC), Beijing, China. hup@sibcb.ac.cn.ORCID http://orcid.org/0000-0001-8832-1391

Zhibin HuAging Biomarker Consortium (ABC), Beijing, China. zhibin_hu@njmu.edu.cn.ORCID http://orcid.org/0000-0002-8277-5234

Canhua HuangAging Biomarker Consortium (ABC), Beijing, China. hcanhua@scu.edu.cn.ORCID http://orcid.org/0000-0003-2247-7750

Jun HuangAging Biomarker Consortium (ABC), Beijing, China. jhuang@zju.edu.cn.ORCID http://orcid.org/0000-0002-7837-653X

Kai HuangAging Biomarker Consortium (ABC), Beijing, China. huangkai1@hust.edu.cn.ORCID http://orcid.org/0000-0002-7121-0318

Pengyu HuangAging Biomarker Consortium (ABC), Beijing, China. huangpengyu@yeah.net.ORCID http://orcid.org/0000-0001-8394-7280

Xunming JiAging Biomarker Consortium (ABC), Beijing, China. jixm@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-0527-2852

Yong JiAging Biomarker Consortium (ABC), Beijing, China. yongji@hrbmu.edu.cn.ORCID http://orcid.org/0000-0003-2650-5747

Shunji JiaAging Biomarker Consortium (ABC), Beijing, China. jiasj@genetics.ac.cn.ORCID http://orcid.org/0000-0001-8678-1714

Hong JiangAging Biomarker Consortium (ABC), Beijing, China. jianghong@uhrs.edu.cn.ORCID http://orcid.org/0000-0003-1524-7519

Wenjian JiangAging Biomarker Consortium (ABC), Beijing, China. jiangwenjian@ccmu.edu.cn.ORCID http://orcid.org/0000-0003-3868-6573

Lingjing JinAging Biomarker Consortium (ABC), Beijing, China. lingjingjin@163.com.ORCID http://orcid.org/0000-0001-7199-2578

Zi-Bing JinAging Biomarker Consortium (ABC), Beijing, China. jinzb502@ccmu.edu.cn.ORCID http://orcid.org/0000-0003-0515-698X

Shenghong JuAging Biomarker Consortium (ABC), Beijing, China. jsh@seu.edu.cn.ORCID http://orcid.org/0000-0001-5041-7865

Zhenyu JuAging Biomarker Consortium (ABC), Beijing, China. zhenyuju2016@jnu.edu.cn.ORCID http://orcid.org/0009-0007-4550-4543

Qing-Peng KongAging Biomarker Consortium (ABC), Beijing, China. kongqp@mail.kiz.ac.cn.ORCID http://orcid.org/0000-0002-6046-4494

Wei KongAging Biomarker Consortium (ABC), Beijing, China. kongw@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-6720-6810

Wei-Jia KongAging Biomarker Consortium (ABC), Beijing, China. entwjkong@hust.edu.cn.ORCID http://orcid.org/0000-0001-5410-2297

Xiangqing KongAging Biomarker Consortium (ABC), Beijing, China. kongxq@njmu.edu.cn.

Guanghua LeiAging Biomarker Consortium (ABC), Beijing, China. lei_guanghua@csu.edu.cn.ORCID http://orcid.org/0000-0003-2987-138X

Geng-Lin LiAging Biomarker Consortium (ABC), Beijing, China. genglin.li@fdeent.org.ORCID http://orcid.org/0000-0001-7053-4284

Ji LiAging Biomarker Consortium (ABC), Beijing, China. liji_xy@csu.edu.cn.ORCID http://orcid.org/0000-0003-0931-5562

Jian LiAging Biomarker Consortium (ABC), Beijing, China. lijian@bjhmoh.cn.ORCID http://orcid.org/0000-0003-3320-7924

Mengfeng LiAging Biomarker Consortium (ABC), Beijing, China. limf@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-5103-6367

Rong LiAging Biomarker Consortium (ABC), Beijing, China. roseli001@sina.com.ORCID http://orcid.org/0000-0003-0305-5579

Wei LiAging Biomarker Consortium (ABC), Beijing, China. leways@gwcmc.org.ORCID http://orcid.org/0000-0002-6235-0749

Wei LiAging Biomarker Consortium (ABC), Beijing, China. liwei@ioz.ac.cn.ORCID http://orcid.org/0000-0001-7864-404X

Xiao-Jun LiAging Biomarker Consortium (ABC), Beijing, China. lixiaojun4183@xjtu.edu.cn.ORCID http://orcid.org/0000-0001-7345-2364

Xin LiAging Biomarker Consortium (ABC), Beijing, China. xinli@ioz.ac.cn.ORCID http://orcid.org/0009-0003-2751-1169

Qingfeng LiangAging Biomarker Consortium (ABC), Beijing, China. liangqingfeng@ccmu.edu.cn.

Zhen LiangAging Biomarker Consortium (ABC), Beijing, China. liangzhen@pkuszh.com.ORCID http://orcid.org/0000-0003-4700-0203

Haotian LinAging Biomarker Consortium (ABC), Beijing, China. linht5@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-4672-9721

Baohua LiuAging Biomarker Consortium (ABC), Beijing, China. ppliew@szu.edu.cn.ORCID http://orcid.org/0000-0002-1599-8059

Cai-Yue LiuAging Biomarker Consortium (ABC), Beijing, China. yueyue1888@hotmail.com.ORCID http://orcid.org/0000-0002-8141-0380

Changsheng LiuAging Biomarker Consortium (ABC), Beijing, China. liucs@ecust.edu.cn.ORCID http://orcid.org/0000-0003-0509-7334

Feng LiuAging Biomarker Consortium (ABC), Beijing, China. liuf001@csu.edu.cn.

Jianfeng LiuAging Biomarker Consortium (ABC), Beijing, China. jfliu@mail.hust.edu.cn.ORCID http://orcid.org/0000-0002-0284-8377

Jun-Ping LiuAging Biomarker Consortium (ABC), Beijing, China. jun-ping.liu@monash.edu.

Ke LiuAging Biomarker Consortium (ABC), Beijing, China. liuke@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-0505-920X

Lin LiuAging Biomarker Consortium (ABC), Beijing, China. liulin@nankai.edu.cn.ORCID http://orcid.org/0000-0001-9881-6830

Pingsheng LiuAging Biomarker Consortium (ABC), Beijing, China. pliu@ibp.ac.cn.ORCID http://orcid.org/0000-0002-2599-9004

Qiang LiuAging Biomarker Consortium (ABC), Beijing, China. qliu@tmu.edu.cn.

Qiang LiuAging Biomarker Consortium (ABC), Beijing, China. liuq2012@ustc.edu.cn.

Tiemin LiuAging Biomarker Consortium (ABC), Beijing, China. tiemin_liu@fudan.edu.cn.ORCID http://orcid.org/0000-0003-2077-7653

Wenwen LiuAging Biomarker Consortium (ABC), Beijing, China. wenwenliu@email.sdu.edu.cn.ORCID http://orcid.org/0000-0001-6031-7972

Xingguo LiuAging Biomarker Consortium (ABC), Beijing, China. liu_xingguo@gibh.ac.cn.ORCID http://orcid.org/0000-0001-7060-8204

Yajun LiuAging Biomarker Consortium (ABC), Beijing, China. drliuyajun@mail.ccmu.edu.cn.

Yong LiuAging Biomarker Consortium (ABC), Beijing, China. liuyong31279@whu.edu.cn.ORCID http://orcid.org/0000-0001-7771-4181

Youhua LiuAging Biomarker Consortium (ABC), Beijing, China. liuyh@smu.edu.cn.ORCID http://orcid.org/0000-0002-4740-805X

Youshuo LiuAging Biomarker Consortium (ABC), Beijing, China. liuyoushuo@csu.edu.cn.ORCID http://orcid.org/0000-0001-9835-4074

Zhili LiuAging Biomarker Consortium (ABC), Beijing, China. zhili-liu@ncu.edu.cn.ORCID http://orcid.org/0009-0008-5835-2769

Xiao LongAging Biomarker Consortium (ABC), Beijing, China. pumclongxiao@126.com.ORCID http://orcid.org/0000-0003-0136-2508

Yao LuAging Biomarker Consortium (ABC), Beijing, China. luyao0719@163.com.ORCID http://orcid.org/0000-0001-6743-7870

Jian LuoAging Biomarker Consortium (ABC), Beijing, China. jluo@tongji.edu.cn.ORCID http://orcid.org/0000-0003-3583-0154

Xianghang LuoAging Biomarker Consortium (ABC), Beijing, China. xianghangluo@csu.edu.cn.ORCID http://orcid.org/0000-0001-6413-572X

Chunhong MaAging Biomarker Consortium (ABC), Beijing, China. machunhong@sdu.edu.cn.ORCID http://orcid.org/0000-0002-8121-4718

Shuai MaAging Biomarker Consortium (ABC), Beijing, China. mashuai@ioz.ac.cn.ORCID http://orcid.org/0000-0002-8858-4383

Xinran MaAging Biomarker Consortium (ABC), Beijing, China. xrma@bio.ecnu.edu.cn.ORCID http://orcid.org/0000-0003-4968-6536

Jianhua MaoAging Biomarker Consortium (ABC), Beijing, China. maojh88@zju.edu.cn.

Zhiyong MaoAging Biomarker Consortium (ABC), Beijing, China. zhiyong_mao@tongji.edu.cn.ORCID http://orcid.org/0000-0002-5298-1918

Shyh-Chang NgAging Biomarker Consortium (ABC), Beijing, China. huangsq@ioz.ac.cn.

Guangjun NieAging Biomarker Consortium (ABC), Beijing, China. niegj@nanoctr.cn.ORCID http://orcid.org/0000-0001-5040-9793

Yuyu NiuAging Biomarker Consortium (ABC), Beijing, China. niuyy@lpbr.cn.ORCID http://orcid.org/0000-0002-8797-4152

Yaojin PengAging Biomarker Consortium (ABC), Beijing, China. yaojin.peng@ioz.ac.cn.

Jun PuAging Biomarker Consortium (ABC), Beijing, China. pujun310@hotmail.com.ORCID http://orcid.org/0000-0003-2240-5108

Jieyu QiAging Biomarker Consortium (ABC), Beijing, China. qijieyu@bit.edu.cn.ORCID http://orcid.org/0000-0001-8780-0710

Li QiangAging Biomarker Consortium (ABC), Beijing, China. qiang@pku.edu.cn.ORCID http://orcid.org/0000-0001-8322-1797

Jie QiaoAging Biomarker Consortium (ABC), Beijing, China. jie.qiao@263.net.ORCID http://orcid.org/0000-0003-2126-1376

Yingying QinAging Biomarker Consortium (ABC), Beijing, China. qinyingying@sdu.edu.cn.ORCID http://orcid.org/0000-0002-0319-7799

Aijuan QuAging Biomarker Consortium (ABC), Beijing, China. aijuanqu@ccmu.edu.cn.

Jing QuAging Biomarker Consortium (ABC), Beijing, China. qujing@ioz.ac.cn.ORCID http://orcid.org/0000-0002-3988-5067

Jie RenAging Biomarker Consortium (ABC), Beijing, China. renjie@big.ac.cn.ORCID http://orcid.org/0000-0002-6450-3163

Ruibao RenAging Biomarker Consortium (ABC), Beijing, China. rbren@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-9783-0064

Xiong Z RuanAging Biomarker Consortium (ABC), Beijing, China. xiongzruan@foxmail.com.

Anbing ShiAging Biomarker Consortium (ABC), Beijing, China. ashi@hust.edu.cn.ORCID http://orcid.org/0000-0003-1128-2026

Haibo ShiAging Biomarker Consortium (ABC), Beijing, China. hbshi@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-2920-0183

Jie ShiAging Biomarker Consortium (ABC), Beijing, China. shijie@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-6567-8160

Kwok-Fai SoAging Biomarker Consortium (ABC), Beijing, China. hrmaskf@hku.hk.

Moshi SongAging Biomarker Consortium (ABC), Beijing, China. songmoshi@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9929-8975

Weihong SongAging Biomarker Consortium (ABC), Beijing, China. weihong@wmu.edu.cn.ORCID http://orcid.org/0000-0001-9928-889X

Zhou SongyangAging Biomarker Consortium (ABC), Beijing, China. songyanz@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-7824-3761

Jiacan SuAging Biomarker Consortium (ABC), Beijing, China. drsujiacan@163.com.ORCID http://orcid.org/0000-0001-7080-263X

Aijun SunAging Biomarker Consortium (ABC), Beijing, China. sun.aijun@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-0109-6967

Liang SunAging Biomarker Consortium (ABC), Beijing, China. sunbmu@foxmail.com.ORCID http://orcid.org/0000-0003-1634-4716

Qiang SunAging Biomarker Consortium (ABC), Beijing, China. sunq@bmi.ac.cn.ORCID http://orcid.org/0000-0002-5342-0637

Yi Eve SunAging Biomarker Consortium (ABC), Beijing, China. yi.eve.sun@gmail.com.ORCID http://orcid.org/0000-0002-1272-3295

Yu SunAging Biomarker Consortium (ABC), Beijing, China. sunyu@sinh.ac.cn.ORCID http://orcid.org/0000-0001-7121-9112

Peifu TangAging Biomarker Consortium (ABC), Beijing, China. pftang301@126.com.ORCID http://orcid.org/0000-0003-4279-1704

Qi-Qun TangAging Biomarker Consortium (ABC), Beijing, China. qqtang@shmu.edu.cn.

Yi TangAging Biomarker Consortium (ABC), Beijing, China. tangyi@xwhosp.org.ORCID http://orcid.org/0000-0001-7235-0227

Jun TaoAging Biomarker Consortium (ABC), Beijing, China. taojungz123@163.com.ORCID http://orcid.org/0000-0002-2226-765X

Ling TaoAging Biomarker Consortium (ABC), Beijing, China. lingtaofmmu@qq.com.

Mei TianAging Biomarker Consortium (ABC), Beijing, China. tianmei@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1587-2114

Xiao-Li TianAging Biomarker Consortium (ABC), Beijing, China. tianxiaoli@ncu.edu.cn.ORCID http://orcid.org/0000-0002-0868-7025

Ye TianAging Biomarker Consortium (ABC), Beijing, China. ytian@genetics.ac.cn.ORCID http://orcid.org/0000-0002-7675-9270

Xiaolin TongAging Biomarker Consortium (ABC), Beijing, China. tongxiaolin@vip.163.com.ORCID http://orcid.org/0000-0002-9873-4154

Cong-Yi WangAging Biomarker Consortium (ABC), Beijing, China. wangcy@tjh.tjmu.edu.cn.ORCID http://orcid.org/0000-0001-7914-168X

Haibo WangAging Biomarker Consortium (ABC), Beijing, China. whboto11@email.sdu.edu.cn.ORCID http://orcid.org/0000-0003-0955-9532

Hongmei WangAging Biomarker Consortium (ABC), Beijing, China. wanghm@ioz.ac.cn.ORCID http://orcid.org/0000-0003-1603-4785

Huating WangAging Biomarker Consortium (ABC), Beijing, China. huating.wang@cuhk.edu.hk.ORCID http://orcid.org/0000-0001-5474-2905

Jianan WangAging Biomarker Consortium (ABC), Beijing, China. wangjianan111@zju.edu.cn.

Jianwei WangAging Biomarker Consortium (ABC), Beijing, China. wangjw28@163.com.

Jianwei WangAging Biomarker Consortium (ABC), Beijing, China. wangjianwei@ihcams.ac.cn.

Jiqiu WangAging Biomarker Consortium (ABC), Beijing, China. wangjq@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-9383-7656

Liheng WangAging Biomarker Consortium (ABC), Beijing, China. lihengwang@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0003-0920-8222

Lin WangAging Biomarker Consortium (ABC), Beijing, China. fierywang@163.com.ORCID http://orcid.org/0000-0001-5586-3012

Miao WangAging Biomarker Consortium (ABC), Beijing, China. miao.wang@pumc.edu.cn.ORCID http://orcid.org/0000-0002-0532-6312

Qiang WangAging Biomarker Consortium (ABC), Beijing, China. qiangwang@scut.edu.cn.ORCID http://orcid.org/0000-0002-8735-8771

Si WangAging Biomarker Consortium (ABC), Beijing, China. wangsi@xwh.ccmu.edu.cn.ORCID http://orcid.org/0000-0003-2431-0612

Sijia WangAging Biomarker Consortium (ABC), Beijing, China. wangsijia@sinh.ac.cn.ORCID http://orcid.org/0000-0001-6961-7867

Songlin WangAging Biomarker Consortium (ABC), Beijing, China. slwang@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-7066-2654

Wengong WangAging Biomarker Consortium (ABC), Beijing, China. wwg@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-1720-809X

Xiaoming WangAging Biomarker Consortium (ABC), Beijing, China. xmwang@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-9671-6358

Xiaoning WangAging Biomarker Consortium (ABC), Beijing, China. xnwang88@163.com.

Yan WangAging Biomarker Consortium (ABC), Beijing, China. Wang.y@whu.edu.cn.ORCID http://orcid.org/0000-0002-3561-3021

Yan-Jiang WangAging Biomarker Consortium (ABC), Beijing, China. yanjiang_wang@tmmu.edu.cn.ORCID http://orcid.org/0000-0002-6227-6112

Yuan WangAging Biomarker Consortium (ABC), Beijing, China. wangyuan980510@163.com.ORCID http://orcid.org/0000-0001-9189-3630

Yunfang WangAging Biomarker Consortium (ABC), Beijing, China. wangyf008@mail.tsinghua.edu.cn.ORCID http://orcid.org/0009-0004-9692-1679

Zhenning WangAging Biomarker Consortium (ABC), Beijing, China. znwang@cmu.edu.cn.ORCID http://orcid.org/0000-0003-0557-3097

Xiawei WeiAging Biomarker Consortium (ABC), Beijing, China. xiaweiwei@scu.edu.cn.ORCID http://orcid.org/0000-0002-6513-6422

Jianping WengAging Biomarker Consortium (ABC), Beijing, China. wengjp@ustc.edu.cn.ORCID http://orcid.org/0000-0002-7889-1697

Haitao WuAging Biomarker Consortium (ABC), Beijing, China. wuht@bmi.ac.cn.ORCID http://orcid.org/0000-0001-8437-3194

Jihong WuAging Biomarker Consortium (ABC), Beijing, China. jihongwu@fudan.edu.cn.ORCID http://orcid.org/0000-0003-3892-5757

Xiaohuan XiaAging Biomarker Consortium (ABC), Beijing, China. xiaohuan_xia1@163.com.ORCID http://orcid.org/0000-0002-0287-6319

Yang XiaAging Biomarker Consortium (ABC), Beijing, China. Yang.Xia1106@CSU.EDU.CN.ORCID http://orcid.org/0000-0002-8059-6179

Andy Peng XiangAging Biomarker Consortium (ABC), Beijing, China. xiangp@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-3409-5012

Guozhi XiaoAging Biomarker Consortium (ABC), Beijing, China. xiaogz@sustech.edu.cn.ORCID http://orcid.org/0000-0002-4269-2450

Junjie XiaoAging Biomarker Consortium (ABC), Beijing, China. junjiexiao@shu.edu.cn.ORCID http://orcid.org/0000-0002-9202-0003

Yichuan XiaoAging Biomarker Consortium (ABC), Beijing, China. ycxiao@sibs.ac.cn.ORCID http://orcid.org/0000-0001-7804-6971

Zhi-Xiong Jim XiaoAging Biomarker Consortium (ABC), Beijing, China. jimzx@scu.edu.cn.ORCID http://orcid.org/0000-0003-2504-5742

Zhengwei XieAging Biomarker Consortium (ABC), Beijing, China. xiezhengwei@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0001-9572-878X

Wei XiongAging Biomarker Consortium (ABC), Beijing, China. wxiong@ustc.edu.cn.ORCID http://orcid.org/0000-0002-1585-3749

Aimin XuAging Biomarker Consortium (ABC), Beijing, China. amxu@hku.hk.ORCID http://orcid.org/0000-0002-0668-033X

Hua XuAging Biomarker Consortium (ABC), Beijing, China. xuhuawhu@163.com.

Lingyan XuAging Biomarker Consortium (ABC), Beijing, China. lyxu@bio.ecnu.edu.cn.ORCID http://orcid.org/0000-0002-8666-5219

Ming XuAging Biomarker Consortium (ABC), Beijing, China. xuminghi@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-1680-3628

Liying YanAging Biomarker Consortium (ABC), Beijing, China. yanliyingkind@aliyun.com.ORCID http://orcid.org/0000-0001-9572-9440

Jiayin YangAging Biomarker Consortium (ABC), Beijing, China. doctoryjy@scu.edu.cn.ORCID http://orcid.org/0000-0003-1623-551X

Jichun YangAging Biomarker Consortium (ABC), Beijing, China. yangj@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-8150-2923

Liu YangAging Biomarker Consortium (ABC), Beijing, China. yangliu@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-6498-4702

Yun-Gui YangAging Biomarker Consortium (ABC), Beijing, China. ygyang@cncb.ac.cn.

Ze YangAging Biomarker Consortium (ABC), Beijing, China. yang_ze@sina.com.ORCID http://orcid.org/0000-0001-8280-523X

Zhenglin YangAging Biomarker Consortium (ABC), Beijing, China. yangzhenglin@cashq.ac.cn.

Hongjie YaoAging Biomarker Consortium (ABC), Beijing, China. yao_hongjie@gzlab.ac.cn.ORCID http://orcid.org/0000-0003-2144-0147

Jing YeAging Biomarker Consortium (ABC), Beijing, China. yj11254@rjh.com.cn.

Chengqi YiAging Biomarker Consortium (ABC), Beijing, China. chengqi.yi@pku.edu.cn.ORCID http://orcid.org/0000-0003-2540-9729

Fan YiAging Biomarker Consortium (ABC), Beijing, China. fanyi@sdu.edu.cn.ORCID http://orcid.org/0000-0001-8634-9788

Honghua YuAging Biomarker Consortium (ABC), Beijing, China. yuhonghua@gdph.org.cn.ORCID http://orcid.org/0000-0002-0782-346X

Yang YuAging Biomarker Consortium (ABC), Beijing, China. yuyang5012@hotmail.com.ORCID http://orcid.org/0000-0002-4310-1966

Zhengrong YuAging Biomarker Consortium (ABC), Beijing, China. dryzr@pku.edu.cn.ORCID http://orcid.org/0009-0005-6979-9935

Ti-Fei YuanAging Biomarker Consortium (ABC), Beijing, China. ytf0707@126.com.ORCID http://orcid.org/0000-0003-0510-715X

Jirong YueAging Biomarker Consortium (ABC), Beijing, China. yuejirong11@hotmail.com.ORCID http://orcid.org/0000-0002-3730-779X

Rui YueAging Biomarker Consortium (ABC), Beijing, China. ryue@tongji.edu.cn.ORCID http://orcid.org/0000-0002-3401-369X

Chen ZhangAging Biomarker Consortium (ABC), Beijing, China. czhang@188.com.ORCID http://orcid.org/0000-0002-7940-8054

Chunxiang ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangchx999@163.com.ORCID http://orcid.org/0000-0003-3308-0265

Cuntai ZhangAging Biomarker Consortium (ABC), Beijing, China. ctzhang0425@163.com.ORCID http://orcid.org/0000-0002-2365-5646

Feng ZhangAging Biomarker Consortium (ABC), Beijing, China. fengzhang@wmu.edu.cn.ORCID http://orcid.org/0000-0002-6751-0377

Hongbo ZhangAging Biomarker Consortium (ABC), Beijing, China. zhanghongbo@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-4081-5752

Hongjia ZhangAging Biomarker Consortium (ABC), Beijing, China. zhanghongjia722@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-5737-4084

Huijie ZhangAging Biomarker Consortium (ABC), Beijing, China. huijiezhang2005@126.com.ORCID http://orcid.org/0000-0003-0640-0315

Jie ZhangAging Biomarker Consortium (ABC), Beijing, China. jiezhang@xmu.edu.cn.ORCID http://orcid.org/0000-0003-1040-5848

Jingjing ZhangAging Biomarker Consortium (ABC), Beijing, China. doctorzhangjj@csu.edu.cn.ORCID http://orcid.org/0000-0002-9155-8979

Licheng ZhangAging Biomarker Consortium (ABC), Beijing, China. zhanglcheng218@126.com.ORCID http://orcid.org/0000-0002-6782-1749

Lingqiang ZhangAging Biomarker Consortium (ABC), Beijing, China. zhanglq@nic.bmi.ac.cn.ORCID http://orcid.org/0000-0002-9795-2141

Luoying ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangluoying@hust.edu.cn.ORCID http://orcid.org/0000-0001-5996-6975

Qingjiong ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangqji@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-7508-848X

Wei ZhangAging Biomarker Consortium (ABC), Beijing, China. ndyfy00266@ncu.edu.cn.

Weiping J ZhangAging Biomarker Consortium (ABC), Beijing, China. wzhang@smmu.edu.cn.ORCID http://orcid.org/0000-0003-4727-2380

Xin ZhangAging Biomarker Consortium (ABC), Beijing, China. xinzhang0805@bjmu.edu.cn.ORCID http://orcid.org/0009-0000-6975-4730

Xuan ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangx@bjhmoh.cn.ORCID http://orcid.org/0000-0001-8775-1699

Yong ZhangAging Biomarker Consortium (ABC), Beijing, China. yongzhang@ibms.pumc.edu.cn.ORCID http://orcid.org/0000-0002-2443-5143

Yun-Wu ZhangAging Biomarker Consortium (ABC), Beijing, China. yunzhang@xmu.edu.cn.ORCID http://orcid.org/0000-0002-7152-7630

Zhanjun ZhangAging Biomarker Consortium (ABC), Beijing, China. zhang_rzs@bnu.edu.cn.ORCID http://orcid.org/0000-0001-7266-4218

Zhuohua ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangzhuohua@sklmg.edu.cn.ORCID http://orcid.org/0000-0002-1394-0697

Bing ZhaoAging Biomarker Consortium (ABC), Beijing, China. bingzhao@ncu.edu.cn.ORCID http://orcid.org/0000-0001-9891-3569

Guoguang ZhaoAging Biomarker Consortium (ABC), Beijing, China. ggzhao@vip.sina.com.ORCID http://orcid.org/0000-0002-7569-5252

Jiajun ZhaoAging Biomarker Consortium (ABC), Beijing, China. jjzhao@sdu.edu.cn.ORCID http://orcid.org/0000-0003-3267-9292

Meng ZhaoAging Biomarker Consortium (ABC), Beijing, China. zhaom38@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-7909-7594

Tongbiao ZhaoAging Biomarker Consortium (ABC), Beijing, China. tbzhao@ioz.ac.cn.ORCID http://orcid.org/0000-0003-1429-5818

Jialin C ZhengAging Biomarker Consortium (ABC), Beijing, China. jialinzheng@tongji.edu.cn.ORCID http://orcid.org/0000-0003-2286-0151

Junke ZhengAging Biomarker Consortium (ABC), Beijing, China. zhengjunke@shsmu.edu.cn.

Zhuozhao ZhengAging Biomarker Consortium (ABC), Beijing, China. zzza00509@btch.edu.cn.ORCID http://orcid.org/0000-0001-8547-6670

Huixia ZhouAging Biomarker Consortium (ABC), Beijing, China. huixia99999@163.com.ORCID http://orcid.org/0000-0002-9911-9495

Lili ZhouAging Biomarker Consortium (ABC), Beijing, China. jinli730@smu.edu.cn.ORCID http://orcid.org/0000-0001-5044-6965

Xiangtian ZhouAging Biomarker Consortium (ABC), Beijing, China. zhouxt@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-1115-561X

Yongsheng ZhouAging Biomarker Consortium (ABC), Beijing, China. kqzhouysh@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0002-4332-0878

Zhongjun ZhouAging Biomarker Consortium (ABC), Beijing, China. zhongjun@hku.hk.ORCID http://orcid.org/0000-0001-7092-8128

Lan ZhuAging Biomarker Consortium (ABC), Beijing, China. zhu_julie@vip.sina.com.ORCID http://orcid.org/0000-0001-5753-5426

Yizhun ZhuAging Biomarker Consortium (ABC), Beijing, China. yzzhu@must.edu.mo.ORCID http://orcid.org/0000-0001-7700-8041

Zhiming ZhuAging Biomarker Consortium (ABC), Beijing, China. hbpcms@sina.com.

Wenjuan ZhuangAging Biomarker Consortium (ABC), Beijing, China. zh_wenj@163.com.ORCID http://orcid.org/0000-0002-8046-3085

Weiguo ZouAging Biomarker Consortium (ABC), Beijing, China. zouwg94@sibcb.ac.cn.ORCID http://orcid.org/0000-0003-2516-0302

Weiqi ZhangAging Biomarker Consortium (ABC), Beijing, China. zhangwq@big.ac.cn.ORCID http://orcid.org/0000-0002-8885-5104

Gang PeiAging Biomarker Consortium (ABC), Beijing, China. peigang@tongji.edu.cn.

Guang-Hui LiuAging Biomarker Consortium (ABC), Beijing, China. ghliu@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9289-8177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions.

Indexed as

AgingAgedAged, 80 and overBiomarkersChinaEast Asian PeopleFemaleHumansMaleMiddle AgedBiomarkers

Identifiers

PMID40926127

DOI10.1093/lifemedi/lnaf001

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