Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation.
Lauren R Borchers, Rotem Dan, Emily L Belleau, Roselinde H Kaiser, Rachel Clegg, Franziska Goer, Pia Pechtel, Miranda Beltzer, Dustin Wooten, Georges El Fakhri and 2 more
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2020 to 2024
$15.9M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Early Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4M
Neuroimaging Studies of Reward Processing in DepressionR01MH068376 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2004 to 2014
$4.5M
Tracking the dynamic trajectory of behavioral, physiological, and neurobiological stress responses in female adolescents at high and low familial risk for depression.R01MH137441 · NIMH · MCLEAN HOSPITAL · PI Emily Belleau · 2025 to 2026
$1.5M
Neural Correlates of Stress and Perceived Control in Adolescent DepressionK23MH122668 · NIMH · MCLEAN HOSPITAL · PI BELLEAU, EMILY · 2020 to 2024
$960k
NIMH NIH HHS K23 MH122668NIMH NIH HHS P50 MH119467NIMH NIH HHS R01 MH068376NIMH NIH HHS R01 MH095809NIMH NIH HHS R01 MH137441NIMH NIH HHS R37 MH068376U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH068376U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH095809Wellcome Trust
6 · The paper itself
Abstract
Dysregulated dopaminergic signaling has been implicated in the pathophysiology of major depressive disorder (MDD) and childhood sexual abuse (CSA), but inconsistencies abound. In a multimodal PET-functional MRI study, harnessing the highly selective tracer [
Indexed as
Child Abuse, SexualMajor Depressive DisorderAdultChildCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMultimodal ImagingNeural PathwaysNeuroimagingPositron-Emission TomographyRewardDopamineDopamine Plasma Membrane Transport Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation. · full record | OpenQuestion