ArticleNature immunology2025
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.Immunology and cell biology · 2026Review
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation.Nature communications · 2026Article
- Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026Review
- Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes inbioRxiv : the preprint server for biology · 2026Article
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- Aging restricts maturation of CXCL13bioRxiv : the preprint server for biology · 2026Article
- Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood.bioRxiv : the preprint server for biology · 2026Article
- Multimodal analysis definesbioRxiv : the preprint server for biology · 2025Article
- Tfh2 and a subset of Tfh1 cells associate with antibody-mediated immunity to malaria.JCI insight · 2025Article
- Lymphatic constraint of germinal centers optimizes protective antibody responses.bioRxiv : the preprint server for biology · 2025Article
- TNature immunology · 2025Article
- Pathway Analysis Interpretation in the Multi-Omic Era.Biotech (Basel (Switzerland)) · 2025Review
- Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination.Clinical & translational immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Lennard Dalit *Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-6159-6640
Chin Wee Tan *Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-9695-7218
Amania A SheikhWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Ryan MunningsWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-6911-7210
Lauren J HowsonWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-3522-4533
Carolina AlvaradoWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0009-0003-2451-3783
Tabinda HussainDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Aidil ZainiDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Lucy CooperDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-7153-5358
Alana KirnDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Lauren HailesDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Angela NguyenDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Bailey E WilliamsWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0009-0007-9438-0778
Ming Z M ZhengDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-5406-7425
Carolien E van de SandtDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-4155-7433
Laura K MackayDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-8496-6632
Katie L FlanaganSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.ORCID http://orcid.org/0000-0002-1575-1953
Katherine KedzierskaDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-6141-335X
Nicola HarrisDepartment of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-2922-0210
Jennifer A JunoDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9072-1017
Colby ZaphDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.
Nicole L La GrutaDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0001-5358-9363
Melissa J DavisWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Stephen L NuttWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-0020-6637
Kim L Good-JacobsonDepartment of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-1891-7274
Vanessa L BryantWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Joanna R GroomWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. groom@wehi.edu.au.ORCID http://orcid.org/0000-0001-5251-7835
Funding
Department of Health | National Health and Medical Research Council (NHMRC) GNT1137989Department of Health | National Health and Medical Research Council (NHMRC) GNT1155342Department of Health | National Health and Medical Research Council (NHMRC) GNT2007812Department of Health | National Health and Medical Research Council (NHMRC) GNT2007884Department of Health | National Health and Medical Research Council (NHMRC) GNT2009308Department of Health | National Health and Medical Research Council (NHMRC) GNT2033037Department of Health | National Health and Medical Research Council (NHMRC) GNT2033783Department of Health | National Health and Medical Research Council (NHMRC) GNT2033880
Abstract
CD4
Indexed as
CytokinesT Follicular Helper CellsT-Lymphocytes, Helper-InducerAnimalsB-LymphocytesGerminal CenterHumansMiceMice, Inbred C57BLSignal TransductionTranscriptomeTransforming Growth Factor betaCytokinesTransforming Growth Factor beta
Identifiers
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.