ArticleBritish journal of cancer2025
The impact of cancer expectations on psychological responses following a cancer signal detected result in asymptomatic multi-cancer detection (MCED) testing.
Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05611632 (A Randomized, Controlled Trial to Assess the Clinical Utility of a Multi-cancer Early Detection), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Controlled Trial to Assess the Clinical Utility of a Multi-cancer Early Detection (MCED) Test for Population Screening in the United Kingdom (UK) When Added to Standard of Care
Who cites it
2 citing papers in PubMed.
- The ethics of multi-cancer screening.Nature medicine · 2026Article
- Experience of NHS diagnostic investigation following a multi-cancer early detection (MCED) screening test: qualitative interviews with NHS-Galleri trial participants who had a cancer signal detected.EClinicalMedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMulti-cancer detection (MCED) blood tests have the potential to screen for early-stage cancers. Understanding how people experience an MCED cancer signal result is vital prior to any future implementation. We explored experiences in a trial context.
methodsA subset of 41 participants in the NHS-Galleri trial (NCT05611632), with a cancer signal detected result, were interviewed. We selected: 20 participants with cancer found (self-reported) and 21 without cancer (following tests). Transcripts were analysed thematically.
resultsExpectations of cancer played a pivotal role in emotional, cognitive and social responses, and were influenced by participants' experiences of health and symptoms. While the cancer signal was often unexpected, the predicted cancer signal origin made sense when consistent with family history or health issues. During the period of diagnostic uncertainty, views of healthiness or lack of family history were sometimes used to self-reassure. For some, a cancer diagnosis was unexpected; for others, expectations of cancer had gradually increased. For those without cancer, believing that it could be present affected their sense of reassurance. DISCUSSION: Information about the meaning of a cancer signal will be needed if MCED screening is implemented. Patient support could be designed around their expectations of cancer at each stage.
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Registered trials
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