Evidence map›Paper›PMID 40926047›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Clinical heterogeneity and prognostic markers in head and neck Kimura disease: A retrospective study.

Yifan Yang, Xue Zhang, Qi Zhong, Yang Zhang, Hongzhi Ma, Lizhen Hou, Shizhi He, Qian Shi, Ru Wang, Jugao Fang and 1 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yifan YangDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Xue ZhangKey Laboratory of Otorhinolaryngology, Head and Neck Surgery, Beijing Institute of Otorhinolaryngology, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Qi ZhongDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Yang ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Hongzhi MaDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Lizhen HouDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Shizhi HeDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Qian ShiDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Ru WangDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Jugao FangDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China.
Ling FengDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, No.1 Dongjiaominxiang Street, Beijing, 100730, China. fengling@ccmu.edu.cn.ORCID http://orcid.org/0009-0001-6533-4795

Funding

Beijing Hospitals Authority Youth Programme QML20230206Beijing Natural Science Foundation 7244308
6 · The paper itself

Abstract

objectiveKimura disease (KD) is a rare, chronic inflammatory disorder that is typically located in the head and neck region. It is characterized by subcutaneous nodules, eosinophilia, and elevated IgE levels. Its unclear etiology and similarities to malignancies create diagnostic and therapeutic challenges. The purpose of this study is to share our treatment experience and explore prognostic factors associated with KD.

methodsWe collected data on KD patients treated at our hospital between June 2013 and May 2024. The data included the patients' demographics, clinical and laboratory profiles, radiological and pathological findings, treatments, and outcomes. Non-normal variables are presented as medians with ranges, and categorical variables are shown as frequencies. We performed statistical comparisons using Mann-Whitney U tests.

resultsThis study analyzed 13 KD patients (median age 44 years, male-to-female ratio 9:4). All patients present with had head and neck lesions. 75.0% showed elevated peripheral eosinophilia, 77.8% had increased blood eosinophilia percentages, and all tested patients had elevated IgE levels. Treatments included surgical excision, glucocorticoids, methotrexate, low-dose radiotherapy, and observation. Remission was achieved in 76.9% of patients. Patients with poor outcomes had significantly higher absolute eosinophil counts (median: 1.77 vs. 0.90 × 10⁹/L, p = 0.04) and percentages (median: 21.4% vs. 12.2%, p = 0.03) than those with favorable outcomes. Imaging misdiagnosis occurred in 38.5% of patients, highlighting the superiority of histopathology for diagnosis. Urine abnormalities, mild renal dysfunction, and uncommon lesion sites were also observed.

conclusionThe clinical heterogeneity of KD requires multidisciplinary management. Pre-treatment eosinophilia is emerging as a prognostic marker. Future studies should prioritize the identification of biomarkers, kinetic surveillance, and targeted biologics in order to reduce recurrence and systemic complications.

Indexed as

Angiolymphoid Hyperplasia with EosinophiliaKimura DiseaseAdolescentAdultAgedEosinophiliaFemaleGlucocorticoidsHeadHumansImmunoglobulin EMaleMiddle AgedNeckPrognosisRetrospective StudiesGlucocorticoidsImmunoglobulin EDiagnostic imagingEosinophiliaHead and neck neoplasmsKimura diseasePathological diagnosis

Identifiers

PMID40926047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.