Evidence map›Paper›PMID 40926035›Full record

GuidelineBone marrow transplantation2025

Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.

R Greco, A Ruggeri, D P McLornan, J A Snowden, T Alexander, E Angelucci, D Averbuch, A Bazarbachi, M D Hazenberg, K Kalwak and 9 more

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07635693 (ATLG Levels and Immune Reconstitution Kinetics in Autologous HSCT for Multiple Sclerosis), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07635693 recruitingnot on this mapstarted 2026, after this paper: background citation

ATLG Levels and Immune Reconstitution Kinetics in Autologous HSCT for Multiple Sclerosis

TypeobservationalSponsorCiceri FabioRan2026 to 2029Enrolled20ConditionsMultiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant, ATLGArmsATLG administration
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Quality of Life in CAR-T Cell Therapy.Hematology reports · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

R Greco *Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy. greco.raffaella@hsr.it.ORCID 0000-0002-6117-5328
A Ruggeri *Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy. Ruggeri.Annalisa@hsr.it.ORCID 0000-0002-7261-2765
D P McLornanDepartment of Haematology and Stem Cell Transplantation, University College London Hospitals NHS Trust, London, UK.ORCID 0000-0003-1224-091X
J A SnowdenDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID 0000-0001-6819-3476
T AlexanderDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-1193-0097
E AngelucciHematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.ORCID 0000-0002-6512-6080
D AverbuchFaculty of Medicine, Hebrew University of Jerusalem; Hadassah Medical Center, Jerusalem, Israel.
A BazarbachiBone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0002-7171-4997
M D HazenbergDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
K KalwakClinical Department of Pediatric BMT, Hematology and Oncology, Wroclaw Medical University, Wroclaw, Poland.ORCID 0000-0003-1174-5799
M KenyonDepartment of Haematology, King's College Hospital NHS Foundation Trust, London, UK.ORCID 0000-0002-1859-6178
H MekelenkampWillem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-4410-1845
B NevenPediatric Immune-Hematology Unit, Necker Children Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.ORCID 0000-0001-8941-0935
P PedrazzoliDepartment of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.ORCID 0000-0002-9419-7160
Z PericUniversity Hospital Centre Rijeka, Rijeka, Croatia.
A M RisitanoHematology and Hematopoietic Transplant Unit, Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati (A.O.R.N. Giuseppe Moscati), Avellino, Italy.ORCID 0000-0002-4744-5109
I Sánchez-OrtegaEBMT Executive Office, Barcelona, Spain.ORCID 0009-0005-5519-9154
F CiceriUnit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0003-0873-0123
A SuredaClinical Hematology Department, Institut Català d'Oncologia-Hospitalet, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), University of Barcelona, Barcelona, Spain.ORCID 0000-0002-1238-6970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the ninth special EBMT report on indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered with the risk of the disease, risk of HCT procedure and non-HCT strategies, including evolving cellular therapies, and their availability on site. HCT techniques are constantly evolving and we make no specific recommendations, but encourage harmonisation of practice, where possible, to ensure experience across indications can be meaningfully aggregated via registry outputs. We also recommend working according to JACIE certification standards to maintain quality in clinical and laboratory practice, including benchmarking of survival outcomes [1-3]. Since the last edition, innovative cellular and gene therapies have entered in activity across indications affecting clinical decision making. As the number and type of regulatory authority-approved cellular therapies grow, recommendations for best practice and quality of patient care were developed to support clinicians and will be regularly updated.

Indexed as

Hematologic DiseasesHematopoietic Stem Cell TransplantationImmune System DiseasesImmunotherapy, AdoptiveNeoplasmsHumans

Identifiers

PMID40926035
PMCPMC12583170

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.