ArticlePediatric research2026
Neonatal characteristics and neurodevelopmental phenotypes in congenital cytomegalovirus.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Development, Testing, and Calibration of LINCS: A New Microsimulation Model of Maternal and Fetal Cytomegalovirus Infection in the United States.MDM policy & practiceArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundChildren with congenital cytomegalovirus (cCMV) have a wide spectrum of possible neurodevelopmental outcomes.
objectivesTo describe neurodevelopmental (ND) Phenotypes of children with cCMV based on medical, developmental, and behavioral outcomes in childhood, and examine whether birth characteristics were associated with ND Phenotype.
methodsCaregivers of children with cCMV (N = 242, child aged 12 months to <11 years) completed survey instruments reporting on the child's birth characteristics, reasons for cCMV testing, and present medical, developmental, and behavioral status. Latent Class Analysis was used to derive empirically driven groupings of outcomes, which we called ND Phenotypes. Chi-square analyses and t-tests examined the association between ND Phenotypes with child characteristics.
resultsFive ND Phenotypes were identified: 1) No sequelae with or without Isolated SNHL (n = 44, 18%), 2) High Medical and Neurodevelopmental Involvement (n = 31, 13%) 3) Some Developmental Delays with Mild Neuromuscular Involvement (n = 49, 20%) 4) Isolated Speech and Language Delays (n = 89, 37%) and 5) Autism and Global Developmental Delay (n = 29, 12%). ND Phenotype membership was predicted by birth characteristics and reason for cCMV testing.
conclusionFive ND Phenotypes of children with cCMV were identified. Future studies should examine stability of class membership over time. IMPACT: Five neurodevelopmental phenotypes of children with congenital cytomegalovirus were identified. All but one phenotype consisted of children with multiple long-term medical and neurodevelopmental sequelae. Physical findings, prematurity and intensive care admission at birth were associated with severity of outcome. Children tested for congenital cytomegalovirus due to a failed newborn hearing screen alone were most likely to have no long-term developmental delays.
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