ReviewHandbook of experimental pharmacology2026
Mechanisms of Location Bias in G Protein-Coupled Receptors.
Review in Handbook of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The working lives of neuronal 5-HTRSC chemical biology · 2026Review
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3 authors.
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Abstract
GPCRs are known for their versatile signaling roles at the plasma membrane; however, recent studies have revealed that these receptors also function within various intracellular compartments, such as endosomes, the Golgi apparatus, and the endoplasmic reticulum. This spatially distinct signaling, termed location bias, allows GPCRs to initiate unique signaling cascades and influence cellular processes-including cAMP production, calcium mobilization, and protein phosphorylation-in a compartment-specific manner. By mapping the impact of GPCR signaling from these subcellular locations, this chapter emphasizes the mechanisms underlying signaling from intracellular receptor pools in diversifying receptor functionality. Such mechanistic insights into location-biased signaling open up novel therapeutic strategies aimed at targeting GPCRs within specific organelles, promising new levels of precision in therapeutic modulation and potential improvements in treatment efficacy and specificity.
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Registered trials
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