ArticleExperimental neurobiology2025
Reproductive Dysfunction in Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis.
Article in Experimental neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Testosterone in Relapsing-Remitting Multiple Sclerosis: A Case-Control Study.Journal of clinical medicine · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). The latter is a human organ-specific autoimmune disease of the central nervous system (CNS). EAE is characterized by systemic inflammation associated with increased blood levels of proinflammatory mediators that potentially trigger inflammation of both reproductive organs and the CNS. Pathological changes in the hypothalamus-pituitary gland-gonadal axis have occasionally been reported in both the MS and EAE contexts. Such changes may affect the reproductive organs. We used the phrase "EAE and hypothalamus-pituitary-gonads (testis and ovary)" to retrieve relevant papers from PubMed. We postulated that EAE might be associated with inflammation of the hypothalamus, pituitary gland and gonads, in turn indicating reproductive dysfunction. This paper overviews evidence supporting the roles of both hormonal and inflammatory alterations in animals with EAE. This aids our understanding of how certain autoimmune diseases are associated with infertility.
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