ArticleBMJ mental health2025
Strong association between psychiatric disorders co-occurrence and dementia: a Bayesian approach on a 14-year clinical data warehouse.
Article in BMJ mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and Incidence of Dementia for Schizophrenia and Other Primary Psychotic Disorders: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Pooled it
- Blood ATX(N) Biomarkers and Cognitive Dysfunction in Severe Mental Illnesses.International journal of molecular sciences · 2026Review
- Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change.Alzheimer's research & therapy · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychiatric disorders alone are associated with an increased risk of developing dementia. However, the relationship between co-occurring psychiatric disorders and dementia odds remains unclear. This study aimed to assess the odds of dementia (all types) among individuals with several psychiatric disorders and identify relevant co-occurrence patterns.
methodsData were extracted from the clinical data warehouse of the psychiatry department of Bicêtre Hospital, France, between 29 August 2009 and 29 October 2023. Patients aged 45 years and older diagnosed with at least one psychiatric disorder-depressive disorders, anxiety disorders, psychotic disorders, substance use disorders, personality disorders or bipolar disorders-were included. Subgroups were created to evaluate specific patterns of psychiatric co-occurrence associated with dementia. In this case-control study, Bayesian models, including hierarchical models and logistic regression adjusted for age, sex and cardiovascular risk factors, were used to estimate posterior probabilities and ORs for dementia.
resultsAmong 3688 subjects, the mean (SD) age at inclusion was 68.7 (12.1) in the dementia group (653 (17.7%) subjects) and 58.2 (10.5) in the non-dementia group (3035 (82.3%) individuals). Compared with those with one psychiatric disorder (2608 (70.7%) patients), the adjusted OR (95% credible interval) for dementia increased from 2.3 (1.7-3) with two comorbidities (789 (21.4%) patients) to 11.1 (5.4-22.2) with four comorbidities (65 (1.8%) subjects). Patients with co-occurrence of mood and anxiety disorders had a mean posterior probability from 48% (34.1-62.2) up to 89.6% (76.8-98.6) of dementia.
conclusionsDementia odds significantly increase with the number of psychiatric comorbidities, with mood and anxiety disorder co-occurrence showing the highest posterior probabilities. Targeted screening strategies should be developed for these patients, with a special focus on patients developing more than one psychiatric disorder.
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