Evidence map›Paper›PMID 40925610›Full record

ArticleThe Journal of infectious diseases2026

Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India.

Prakruti S Rao, Senbagavalli Prakash Babu, Komala Ezhumalai, Selby Knudsen, Jayalakshmy Ramakrishnan, Noyal Joseph, Chelsie Cintron, Madolyn R Dauphinais, Prakash Babu Narasimhan, Padmini Salgame and 7 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Prakruti S RaoDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Senbagavalli Prakash BabuDepartment of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Komala EzhumalaiDepartment of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Selby KnudsenBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.
Jayalakshmy RamakrishnanDepartment of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.ORCID 0000-0002-7798-5616
Noyal JosephDepartment of Microbiology, JIPMER, Puducherry, India.ORCID 0000-0001-6586-2742
Chelsie CintronBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.ORCID 0000-0001-6981-1061
Madolyn R DauphinaisBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.ORCID 0000-0003-4319-9788
Prakash Babu NarasimhanMGMARI, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India.ORCID 0000-0001-7111-7124
Padmini SalgameDepartment of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0003-2245-3767
Natasha S HochbergBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.
David L HomDepartment of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0009-0003-0778-2076
Scott K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Charles Robert HorsburghBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.
Jerrold J EllnerDepartment of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0001-6150-0082
Pranay SinhaBoston Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.
Sonali SarkarDepartment of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Funding

Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and AdultsR01AI137080 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, Leonid Kagan · 2018 to 2026
$6.3M
Impact of Pregnancy on TuberculosisR01AI124217 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ELLNER, JERROLD J. · 2015 to 2018
$2.6M
Nutritional Interventions to End Tuberculosis among Persons with HIV (NUTRIENT)K01AI167733 · NIAID · BOSTON MEDICAL CENTER · PI Pranay Sinha · 2023 to 2026
$512k
NIAID NIH HHS K01 AI167733NIAID NIH HHS K01AI167733NIAID NIH HHS R01 AI124217NIAID NIH HHS R01AI124217NIAID NIH HHS R01 AI137080NIAID NIH HHS R01AI137080University of Virginia's Center for Global Health Equity
6 · The paper itself

Abstract

This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and nonpregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.

Indexed as

Antitubercular AgentsPregnancy Complications, InfectiousRifampinTuberculosisAdolescentAdultFemaleHumansIndiaPregnancyProspective StudiesYoung AdultAntitubercular AgentsRifampinIndiapharmacokineticspregnancyrifampintuberculosis

Identifiers

PMID40925610
PMCPMC13016651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.