Evidence map›Paper›PMID 40925504›Full record

ArticleMicrovascular research2026

Sex differences in near-infrared spectroscopy reactive hyperemia: Influence of adipose tissue and desaturation rate.

Matthew A Chatlaong, Hannah C Dowell, Orlandria J Smith, Matthew B Jessee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microvascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Matthew A ChatlaongUniversity of Cincinnati, Exercise Science - School of Human Services, Cincinnati, OH, USA. Electronic address: chatlama@ucmail.uc.edu.
Hannah C DowellApplied Human Health and Physical Function Laboratory, University of Mississippi, Department of Health, Exercise Science, and Recreation Management, University, MS, USA.
Orlandria J SmithApplied Human Health and Physical Function Laboratory, University of Mississippi, Department of Health, Exercise Science, and Recreation Management, University, MS, USA.
Matthew B JesseeApplied Human Health and Physical Function Laboratory, University of Mississippi, Department of Health, Exercise Science, and Recreation Management, University, MS, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Sex differences in near-infrared spectroscopy (NIRS) reactive hyperemia outcomes have been previously reported, with females generally having a lower reperfusion slope. Sex differences have also been reported for adipose tissue thickness (ATT), which affects the NIRS signal, and desaturation during occlusion, which may act on reperfusion slopes. We aimed to compare statistically adjusted and unadjusted sex differences in reperfusion slope during reactive hyperemia.

methods23 female and 22 male participants completed forearm and thigh vascular occlusion tests. ATT was measured via ultrasound. Reperfusion slopes (StO

resultsIn both limbs, females had greater ATT (p < 0.001). Desaturation rate was lower in females for the leg (-0.02 [-0.03, -0.01]), but not the arm (0.00 [-0.01, 0.02]). Unadjusted, males had greater reperfusion slope in the leg (females = 0.91 [0.70, 1.11], males = 1.59 [1.33, 1.85], p < 0.001) but not the arm (females = 1.60 [1.36, 1.84], males = 1.57 [1.29, 1.86], p = 0.874). Sex differences were not observed in adjusted models (both p ≥ 0.631). ATT and desaturation slope explained unique variance in the leg (both p ≤ 0.001), but only desaturation slope did in the arm (p < 0.001).

conclusionSex differences may have been related to differing ATT and desaturation rates. Researchers may consider adjusting for ATT and/or desaturation rate when estimating sex differences with NIRS reactive hyperemia.

Indexed as

Adipose TissueAdiposityHyperemiaMicrocirculationOxygenOxygen SaturationAdultFemaleForearmHumansMaleMiddle AgedPredictive Value of TestsRegional Blood FlowSex FactorsSpectroscopy, Near-InfraredOxygenNormalizationSlope 1Slope 2Vascular function

Identifiers

PMID40925504
PMCPMC13479139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.