ReviewDevelopmental cell2025
Defining breast epithelial cell types in the single-cell era.
Abstract readReview
In one paragraph
Review in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Single-cell multi-omic profiling of heterogeneous PROCRiScience · 2026Article
- Article
- Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming.Nature biotechnology · 2026Article
- Dynamics, function, and regulation of mammary stem cells in development and disease.Experimental & molecular medicine · 2026Review
- Mouse genetic mosaic model for basal-like breast cancer reveals disruption of basal-myoepithelial architecture at premalignancy.Research square · 2026Article
- Integrated Single-Nucleus Multi-Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Cell Ontology in the age of single-cell omics.Scientific data · 2026Article
- Serial Spatial Transcriptomics Reveal Divergent Routes to Therapy Resistance in Metastatic Breast Cancer.Research square · 2026Article
- The Human Male Mammary Gland has Similar Epithelial Populations to Female but Distinct Composition and Transcriptional Properties.bioRxiv : the preprint server for biology · 2026Article
- Single cell RNA-sequencing reveals that testosterone reduces estrogen signaling in the healthy human mammary gland.Journal of mammary gland biology and neoplasia · 2026Article
- Low- and high-dose-rate radiation exposure alters the cellular composition and dynamics of the rat mammary epithelium for weeks preceding carcinogenesis.Journal of radiation research · 2026Article
- Region-aware bridge modeling enables interpretable mesoscale representation of spatial transcriptomic tissue sections.Bioinformatics advances · 2026Article
- A cell-based model approach to radiation-induced breast cancer development.Frontiers in public health · 2026Article
- Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation.Journal of mammary gland biology and neoplasia · 2025Review
- Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer.Cancer heterogeneity and plasticity · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
G Kenneth GrayDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: gkennethgray@gmail.com.
Eric G CarlsonBeckman Research Institute, City of Hope, Duarte, CA, USA.
Tatyana LevCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.
Bailey MarshallChan Zuckerberg Initiative Foundation, Redwood City, CA, USA.
Austin D ReedDepartment of Pharmacology, University of Cambridge, Cambridge, UK; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Alex P Sánchez-CovarrubiasDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Alecia-Jane TwiggerDepartment of Pharmacology, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Aleix Puig-BarbeEMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.
Aatish ThennavanDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ayodele OmotosoDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Lyndsay M MurrowGenentech, South San Francisco, CA, USA.
Deeptiman ChatterjeeCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Siyuan HeDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sara PensaDepartment of Pharmacology, University of Cambridge, Cambridge, UK; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Brian AevermannChan Zuckerberg Initiative Foundation, Redwood City, CA, USA.
Norbert K TavaresChan Zuckerberg Initiative Foundation, Redwood City, CA, USA.
Natalie ChenHematology and Oncology, Baylor College of Medicine, Houston, TX, USA.
Jason A HiltonDepartment of Genetics, Stanford University, Stanford, CA, USA.
Kerrigan BlakeCellarity, Cambridge, MA, USA.
Yunlong LiuCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.
Kiet PhongDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Zev J GartnerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Devon A LawsonCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Alexander SwarbrickCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia.
Camila O Dos SantosCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Sophia H L GeorgeDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Joan S BruggeDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Boston, MA, USA.
Mark A LaBargeBeckman Research Institute, City of Hope, Duarte, CA, USA.
Harikrishna NakshatriDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Veterans Affairs Roudebush Medical Center, Indianapolis, IN, USA.
Nicholas NavinDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kai KessenbrockDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA. Electronic address: kai.kessenbrock@uci.edu.
Walid T KhaledDepartment of Pharmacology, University of Cambridge, Cambridge, UK; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Electronic address: wtk22@cam.ac.uk.
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M3D Multiscale Biomolecular Human Reference Atlas Construction, Visualization and Usage [4 of 5]OT2OD033756 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI BORNER, KATY · 2022 to 2025
$7.4MProbing the role of epigenomics in Brca1-deficient mammary tumors.R01CA248158 · NCI · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$2.2MBlockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary glandR01CA284630 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Camila dos Santos · 2023 to 2026
$1.9MDefining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiationR01AG069727 · NIA · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$1.8MBLRD VA I01 BX007249BLRD VA IK6 BX005244NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA248158NCI NIH HHS R01 CA284630NIA NIH HHS R01 AG069727NIH HHS OT2 OD033756
Abstract
Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.
Indexed as
BreastEpithelial CellsMammary Glands, HumanSingle-Cell AnalysisFemaleHumansbreasthierarchical differentiationhuman biologylactationmammary glandnomenclaturesingle-cell biologytissue organization
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.