Evidence map›Paper›PMID 40924944›Full record

ArticleEmerging topics in life sciences2025

The impact of artificial intelligence on biomarker discovery.

Hira Javaid, Constantin Cezar Petrescu, Lisa J Schmunk, Jack M Monahan, Paul O'Reilly, Manik Garg, Leona McGirr, Mahmoud T Khasawneh, Mustafa Al Lail, Deepak Ganta and 4 more

Abstract read
In one paragraph

Article in Emerging topics in life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Review
  6. Review
  7. Review
  8. Deep learning for psychiatric genomics: from tools to applications.Current opinion in genetics & development · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Applications of artificial intelligence in drug discovery.Emerging topics in life sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hira JavaidHurdle.bio / Chronomics Ltd., London, UK.
Constantin Cezar PetrescuHurdle.bio / Chronomics Ltd., London, UK.ORCID 0009-0003-4359-2894
Lisa J SchmunkHurdle.bio / Chronomics Ltd., London, UK.ORCID 0009-0009-0879-462X
Jack M MonahanBiomodal Ltd, The Trinity Building, Chesterford Business Park, Cambridge, UK.ORCID 0000-0002-0635-0015
Paul O'ReillySonrai Analytics Ltd, Queens Road, Belfast, Northern Ireland, UK.
Manik GargCentre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0003-0453-2058
Leona McGirrHurdle.bio / Chronomics Ltd., London, UK.
Mahmoud T KhasawnehTexas A&M International University, Laredo, Texas, U.S.A.
Mustafa Al LailTexas A&M International University, Laredo, Texas, U.S.A.
Deepak GantaTexas A&M International University, Laredo, Texas, U.S.A.ORCID 0000-0001-8486-5463
Thomas M StubbsHurdle.bio / Chronomics Ltd., London, UK.ORCID 0000-0002-2990-7381
Benjamin B SunBristol Myers Squibb, New York, U.S.A.ORCID 0000-0001-6347-2281
Dimitrios VitsiosCentre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0002-8939-5445
Daniel E Martin-HerranzHurdle.bio / Chronomics Ltd., London, UK.ORCID 0000-0002-2285-3317

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) is transforming many fields, including healthcare and medicine. In biomarker discovery, AI algorithms have had a profound impact, thanks to their ability to derive insights from complex high-dimensional datasets and integrate multi-modal datatypes (such as omics, electronic health records, imaging or sensor and wearable data). However, despite the proliferation of AI-powered biomarkers, significant hurdles still remain in translating them to the clinic and driving adoption, including lack of population diversity, difficulties accessing harmonised data, costly and time-consuming clinical studies, evolving AI regulatory frameworks and absence of scalable diagnostic infrastructure. Here, we provide an overview of the AI toolkit available for biomarker discovery, and we discuss exciting examples of AI-powered biomarkers across therapeutic areas. Finally, we address the challenges ahead of us to ensure that these technologies reach patients and users globally and unlock a new era of fast innovation for precision medicine.

Indexed as

artificial intelligencebiomarker discoverybiomarkersdiagnosticselectronic health recordsmulti-modal datamulti-omics

Identifiers

PMID40924944
PMCPMC12802349

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.