Evidence map›Paper›PMID 40924873›Full record

ArticleJournal of the American Chemical Society2025

Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR.

Roman Zadorozhnyi, Caitlin M Quinn, Kaneil K Zadrozny, Sherimay D Ablan, Brandon J Kennedy, Glenn P A Yap, Daniel Sanner, Christina Kraml, Eric O Freed, Barbie K Ganser-Pornillos and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Synthesis ofMagnetic resonance in chemistry : MRC · 2026
    Article
  2. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Roman ZadorozhnyiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Caitlin M QuinnDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0001-6172-7324
Kaneil K ZadroznyDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Sherimay D AblanCenter for Cancer Research, National Cancer Institute, HIV Dynamics and Replication Program, Frederick, Maryland 21702, United States.
Brandon J KennedyLotus Separations LLC, Princeton University, Princeton, New Jersey 08540, United States.
Glenn P A YapDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0003-0385-387X
Daniel SannerLotus Separations LLC, Princeton University, Princeton, New Jersey 08540, United States.
Christina KramlLotus Separations LLC, Princeton University, Princeton, New Jersey 08540, United States.
Eric O FreedCenter for Cancer Research, National Cancer Institute, HIV Dynamics and Replication Program, Frederick, Maryland 21702, United States.
Barbie K Ganser-PornillosDepartment of Biochemistry, University of Utah Salt Lake City, Utah 84112, United States.
Owen PornillosDepartment of Biochemistry, University of Utah Salt Lake City, Utah 84112, United States.
Angela M GronenbornDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0001-9072-3525
Tatyana PolenovaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-0346-1131

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christopher R Aiken · 2022 to 2026
$30.6M
Macromolecular X-ray Crystallographic Data Collection SystemS10OD026896 · OD · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 2020 to 2020
$580k
NIAID NIH HHS U54 AI170791NIH HHS S10 OD026896
6 · The paper itself

Abstract

Among the different types of HIV-1 maturation inhibitors, those that stabilize the junction between the capsid protein C-terminal domain (CA

Indexed as

Anti-HIV AgentsHIV-1HumansModels, MolecularNuclear Magnetic Resonance, BiomolecularPhytic AcidAnti-HIV AgentsPhytic Acid

Identifiers

PMID40924873
PMCPMC12831462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.