ArticlePloS one2025
Efficacy and mechanism of high-purity HAMCC combined with CGF in promoting the repair of radiation-induced skin and soft tissue damage.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Efficacy and Safety Analysis of Concentrated Growth Factor Combined with Photorejuvenation for Sensitive Skin Patients: A Retrospective Cohort Study.Clinical, cosmetic and investigational dermatology · 2026Article
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Authors and funding
7 authors.
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Abstract
Radiotherapy, a prevalent and effective treatment for various malignancies, often causes collateral damage to normal skin and soft tissues in the irradiated area. To address this, we developed a novel approach combining SVFG-modified adipose-derived high-activity matrix cell clusters (HAMCC) with concentrated growth factors (CGF) to enhance regeneration and repair of radiation-induced skin and soft tissue injuries. Our study included cellular assays, wound healing evaluations, and histological analyses. In the inflammatory wound healing environment, this treatment reduced ROS and 8-oxo-dG expression while increasing four antioxidant-related proteins (Nrf2, HO-1, NQO1, AKR1C1), thereby suppressing oxidative stress and improving wound healing efficiency. Additionally, the HAMCC and CGF combination promoted collagen expression and rearrangement and accelerated angiogenesis. This innovative treatment presents a promising strategy for regenerating and repairing radiation-induced skin and soft tissue damage.
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