Observational studyPloS one2025
Kidney stone disease increases the risk of cardiovascular events.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKidney stone disease is associated with numerous cardiovascular risk factors. However, the findings across studies are non-uniformly consistent, and the control of confounding variables remains suboptimal. This study aimed to investigate the association between kidney stone and cardiovascular disease.
methodsWe conducted an observational study using data from the National Health and Nutrition Examination Survey conducted between 2007 and 2010. Weighted multivariable-adjusted logistic regression was used to evaluate the association between kidney stones and cardiovascular event risk. Moreover, in observational studies, Mendelian randomization (MR) was applied to avoid reverse causality and reduce the influence of potential confounding factors. Inverse-variance weighted (IVW) was the main analytical method.
resultsAfter controlling for cardiovascular and kidney stone risk factors among 7210 US adults, along with other potential confounding variables, patients with kidney stones exhibited a significantly elevated risk of acute myocardial infarction (AMI) (odds ratio [OR], 1.88 [95% confidence interval [CI], 1.09-3.26], P < 0.05). However, a non-significant association was observed with heart failure, hypertension, or stroke. MR analyses further indicated that genetically predicted kidney stones were causally associated with an increased risk of coronary heart disease (OR, 1.07 [95% CI, 1.04-1.53], P = 0.028), myocardial infarction (OR, 1.08 [95% CI,1.02-1.15], P = 0.015), hypertension (OR 1.01 [95% CI, 1.00-1.02], P = 0.042) and ischemic stroke (OR, 0.86 [95% CI, 0.75-0.98], P = 0.022) in IVW models, with non-significant associations detected for heart failure.
conclusionsThe occurrence of kidney stones has been associated with an elevated risk of myocardial infarction within the context of cardiovascular events. However, cross-sectional analyses yield results that are inconsistent with those obtained from Mendelian randomization analyses regarding outcomes such as heart failure, hypertension, and stroke.
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