ArticleScience progress
Unraveling the link: Is Parkinson's disease a causal factor for glaucoma? Insights from Mendelian randomization.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glaucoma and Systemic Neurodegenerative Diseases: The Brain-Eye Continuum.Journal of current glaucoma practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundGlaucoma is recognized as the second-leading cause of complete blindness in developed countries and a significant contributor to irreversible vision loss worldwide. Understanding the potential genetic links between neurodegenerative diseases, such as Parkinson's disease, and glaucoma is crucial for developing preventive strategies.MethodsThis study utilized data from Genome-Wide Association Studies databases, focusing on European populations without gender restrictions. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables based on criteria ensuring no direct association with outcomes and independence from confounding factors. Mendelian randomization analyses were conducted to assess the relationship between SNP effect sizes for Parkinson's disease and the risk of developing glaucoma. Finally, detailed information on high-risk SNP loci was queried and compared in the Ensembl gene database to further explore the relationship between the two diseases.ResultsThe analysis revealed that for every one standard deviation increase in the SNP effect size for Parkinson's disease, the risk of developing glaucoma increased by 0.3% to 11.9%. Pleiotropy testing indicated a
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.