Evidence map›Paper›PMID 40924588›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Strategic Design of Aptamer-Guided Aggregation-Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer.

Charlie C H Ma, Qingqing Liu, Yue Sui, Wutong Du, Kristy W K Lam, Jacky W Y Lam, Chao Li, Tengteng Chen, Jianwei Sun, Nuomin Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Charlie C H MaDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.ORCID https://orcid.org/0000-0002-1864-4328
Qingqing LiuSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Yue SuiSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Wutong DuDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Kristy W K LamDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Jacky W Y LamDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Chao LiDepartment of Chemistry, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Tengteng ChenDepartment of Chemistry, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Jianwei SunDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.
Nuomin LiThe Ninth Medical Center of Chinese PLA General Hospital, Beijing, 100101, P. R. China.
Ryan T K KwokDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.ORCID https://orcid.org/0000-0002-6866-3877
Jianping ChenSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Feiyi SunThe Ninth Medical Center of Chinese PLA General Hospital, Beijing, 100101, P. R. China.
Ben Zhong TangDepartment of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077, P. R. China.ORCID https://orcid.org/0000-0002-0293-964X

Funding

Innovation and Technology Commission ITC-CNERC14SC01Innovation and Technology Commission ITCRD/17-9Research Grant Council of Hong Kong 16303221Research Grant Council of Hong Kong C6014-20WScience Technology Innovation Commission of Shenzhen Municipality 2023YFB3810001Science Technology Innovation Commission of Shenzhen Municipality JCYJ20220818103007014Science Technology Innovation Commission of Shenzhen Municipality KQTD20210811090142053Shenzhen Key Laboratory of Functional Aggregate Materials ZDSYS20211021111400001
6 · The paper itself

Abstract

Breast cancer (BC), characterized by its heterogeneity and diverse subtypes, necessitates personalized treatment strategies. This study presents MF3Ec-TBPP nanoparticles (NPs) as a promising approach, integrating an aggregation-induced emission (AIE)-based photosensitizer, TBPP, with the MF3Ec aptamer to enhance targeted photodynamic therapy (PDT) for Luminal A subtype BC cells. The nanoparticles also feature a 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) shell and dipalmitoyl phosphatidylcholine (DPPC), which stabilize the structure and inhibit singlet oxygen generation, effectively reducing off-target effects and protecting healthy tissues. Comprehensive in vitro and in vivo studies validate the NPs' specificity and effectiveness in targeting MCF-7 BC cells, achieving significant tumor growth inhibition with minimal damage to surrounding tissues. This study highlights the dual functionality of MF3Ec-TBPP NPs for both diagnosis and treatment, showcasing their potential to improve patient outcomes through precise diagnostic and therapeutic interventions.

Indexed as

Aptamers, NucleotideBreast NeoplasmsNanoparticlesPhotochemotherapyPhotosensitizing AgentsAnimalsFemaleHumansMCF-7 CellsMiceAptamers, NucleotidePhotosensitizing Agentsaggregation‐induced emissionaptamerbreast cancernanoparticlesphotodynamic therapy

Identifiers

PMID40924588
PMCPMC12631910

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.