Evidence map›Paper›PMID 40924579›Full record

ArticleSTAR protocols2025

Protocol for constructing an accessible exposure chamber for in vitro and in vivo modeling of airway environmental exposures.

Abdo Durra, Caroline Cherry, Coline Luo, Emily Huo, Isabella Passamano, Kristen Castillo, Andrew J Lund, Woosuk Choi, Chandani Sen, Rachana Chandran and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdo DurraUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: adurra@ucla.edu.
Caroline CherryUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; UCLA Environmental and Molecular Toxicology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Coline LuoUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Emily HuoUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Isabella PassamanoUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Kristen CastilloUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Andrew J LundUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Woosuk ChoiUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Chandani SenUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Rachana ChandranUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Tammy M RickabaughUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Brigitte N GompertsUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; UCLA Environmental and Molecular Toxicology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, UCLA, Los Angeles, CA 90095, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address: bgomperts@mednet.ucla.edu.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
NCI NIH HHS P30 CA016042
6 · The paper itself

Abstract

Exposure systems to study the effects of environmental exposures can be costly to purchase and difficult to use. Here, we present an accessible and cost-effective approach to building an exposure chamber in the lab. We describe steps for constructing the exposure system and writing the code to run it and simple instructions for experiments using the system. The exposure chamber can be adapted to expose airway cells or lab mice to combustible cigarette smoke, electronic cigarette vapors, or woodfire smoke. For complete details on the use and execution of this protocol, please refer to Durra et al.

Indexed as

Atmosphere Exposure ChambersEnvironmental ExposureAnimalsHumansMiceSmokeSmokeBiotechnology and bioengineeringenvironmental scienceshealth Sciences

Identifiers

PMID40924579
PMCPMC12451164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.