Evidence map›Paper›PMID 40924544›Full record

ArticleBioinformatics (Oxford, England)2025

PEtab.jl: advancing the efficiency and utility of dynamic modelling.

Sebastian Persson, Fabian Fröhlich, Stephan Grein, Torkel Loman, Damiano Ognissanti, Viktor Hasselgren, Jan Hasenauer, Marija Cvijovic

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sebastian PerssonDepartment of Mathematical Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Fabian FröhlichDynamics of Livings Systems Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
Stephan GreinLife and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, 53113, Germany.ORCID 0000-0001-9524-6633
Torkel LomanComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, MA 02139, United States.
Damiano OgnissantiDepartment of Mathematical Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Viktor HasselgrenDepartment of Mathematical Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Jan HasenauerLife and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, 53113, Germany.ORCID 0000-0002-4935-3312
Marija CvijovicDepartment of Mathematical Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.ORCID 0000-0002-5142-5100

Funding

Cancer Research UK CC2242Francis Crick InstituteGerman Research Foundation 432325352German Research Foundation 443187771Swedish Foundation for Strategic Research FFL15-0238Swedish Research Council VR2023-04319Wellcome Trust CC2242
6 · The paper itself

Abstract

summaryDynamic models represent a powerful tool for studying complex biological processes, ranging from cell signalling to cell differentiation. Building such models often requires computationally demanding modelling workflows, such as model exploration and parameter estimation. We developed two Julia-based tools: SBMLImporter.jl, an SBML importer, and PEtab.jl, an importer for parameter estimation problems in the PEtab format, designed to streamline modelling processes. These tools leverage Julia's high-performance computing capabilities, including symbolic pre-processing and advanced ODE solvers. PEtab.jl aims to be a Julia-accessible toolbox that supports the entire modelling pipeline from parameter estimation to identifiability analysis. AVAILABILITY AND IMPLEMENTATION: SBMLImporter.jl and PEtab.jl are implemented in the Julia programming language. Both packages are available on GitHub (github.com/sebapersson/SBMLImporter.jl and github.com/sebapersson/PEtab.jl) as officially registered Julia packages, installable via the Julia package manager. Each package is continuously tested and supported on Linux, macOS, and Windows.

Indexed as

Computational BiologyModels, BiologicalSoftwareProgramming Languages

Identifiers

PMID40924544
PMCPMC12457741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.