Evidence map›Paper›PMID 40924458›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis.

Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Kyoko Jinnai, Shu Kondo, Akira Nakamura, Yoichi Hayakawa, Ryusuke Niwa

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Takashi MatsumuraLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan.ORCID 0000-0002-5817-8819
Masasuke RyudaAnalytical Research Center for Experimental Sciences, Saga University, Saga 840-8502, Japan.ORCID 0000-0001-5390-3797
Hitoshi MatsumotoDepartment of Applied Biological Science, Saga University, Saga 840-8502, Japan.
Takumi KamiyamaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan.
Kyoko JinnaiDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
Shu KondoDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.ORCID 0000-0002-4625-8379
Akira NakamuraInstitute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.ORCID 0000-0001-6506-9146
Yoichi HayakawaDepartment of Applied Biological Science, Saga University, Saga 840-8502, Japan.ORCID 0000-0002-7631-4909
Ryusuke NiwaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan.ORCID 0000-0002-1716-455X

Funding

Kumamoto University K24-15MEXT | Japan Society for the Promotion of Science (JSPS) 19J12272MEXT | Japan Society for the Promotion of Science (JSPS) 22KJ0339MEXT | Japan Society for the Promotion of Science (JSPS) 24K18156MEXT | Japan Society for the Promotion of Science (JSPS) JPMXP1323015486
6 · The paper itself

Abstract

All organisms are exposed to various stressors, which can sometimes lead to organismal death, depending on their intensity. While stress-induced organismal death has been observed in many species, the underlying mechanisms remain unclear. In this study, we investigated the molecular mechanisms of stress-induced organismal death in the fruit fly

Indexed as

Drosophila melanogasterDrosophila ProteinsHeat-Shock ResponseStress, PhysiologicalTOR Serine-Threonine KinasesTranscription FactorsAnimalsCentral Nervous SystemLarvaSignal TransductionDrosophila ProteinsTOR Serine-Threonine KinasesTranscription FactorsmTORorganismal deathproteasestresstranscription factor

Identifiers

PMID40924458
PMCPMC12452862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.