Evidence map›Paper›PMID 40924448›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Climate warming is expanding dengue burden in the Americas and Asia.

Marissa L Childs, Kelsey Lyberger, Mallory J Harris, Marshall Burke, Erin A Mordecai

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Impacts of climate change on dengue.Nature reviews. Microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Waste Generation in Pediatric Orthopaedic Hardware Removal Surgery.Journal of the Pediatric Orthopaedic Society of North America · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Marissa L Childs *Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195.ORCID 0000-0002-8597-2161
Kelsey Lyberger *Department of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0003-4903-380X
Mallory J HarrisDepartment of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8196-0430
Marshall BurkeDoerr School of Sustainability, Stanford University, Stanford, CA 94305.ORCID 0000-0003-4288-5858
Erin A MordecaiDepartment of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-4402-5547

Funding

Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
The child health impacts of overlapping vector-borne diseases in KenyaR01AI102918 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud · 2013 to 2026
$7.7M
Leveraging environmental drivers to predict vector-borne disease transmissionR35GM133439 · NIGMS · STANFORD UNIVERSITY · PI Erin Mordecai · 2019 to 2026
$3.2M
Modeling the influence of temperature on the evolution of vector-virus interactionsR01AI168097 · NIAID · WADSWORTH CENTER · PI Alexander Timothy Ciota · 2022 to 2026
$2.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI102918HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI168097HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM133439NIEHS NIH HHS T32 ES007069NSF | BIO | Division of Biological Infrastructure (DBI) 220894NSF | BIO | Division of Environmental Biology (DEB) DEB-2011147
6 · The paper itself

Abstract

Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas. We found a nonlinear relationship between temperature and dengue incidence with the largest impact of warming at lower temperatures, peak incidence at 27.8°C, and a decline at higher temperatures. Using this inferred temperature response, we estimate 18% (95% CI: 11 to 27%) of historical dengue incidence on average across our study countries is attributable to anthropogenic warming. Future warming could further increase incidence by 49% (95% CI: 16 to 136%) to 76% (95% CI: 27 to 239%) by midcentury for low or high emissions scenarios, respectively, with cooler regions projected to double in incidence due to warming while other currently hot regions experience little impact or even small declines. Under the highest emissions scenario, we estimate that 262 million people are currently living in places in these 21 countries where dengue incidence is expected to more than double due to climate change by midcentury. These insights highlight the major impacts of anthropogenic warming on dengue burden across most of its endemic range, providing a foundation for public health planning and the development of strategies to mitigate future risks due to climate change.

Indexed as

Climate ChangeDengueGlobal WarmingAmericasAnimalsAsiaHumansIncidenceTemperatureclimate attributiondengue feverinfectious disease

Identifiers

PMID40924448
PMCPMC12452855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.