ReviewApplied biochemistry and biotechnology2025
Exploration of Comprehensive Structural and Functional Potential of Recombinant Proteins Using Cutting-Edge Bioinformatics Tools.
Review in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Selective α-Amylase Inhibition by Plant Defensins: Structural Determinants, Engineering Strategies, and Translational Prospects.Probiotics and antimicrobial proteins · 2026Review
- Improving trehalose production through the design and optimization of linker peptides in scaffold protein.Bioprocess and biosystems engineering · 2026Article
- Improved thermostability of Thermobifida fusca mannanase obtained by error-prone PCR mutagenesis.Biotechnology letters · 2026Article
- Computational Characterization of Pathogenic LMNA Missense Variants: Structural Instability, Altered Binding, and Conformational Dynamics.Human mutation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant DNA technology is widely used to produce industrially and pharmaceutically important proteins. In silico analysis, performed before executing wet lab experiments has been greatly helpful in this connection. A shift in protein analysis has been observed over the past decade, driven by advancements in bioinformatics databases, tools, software, and web servers. Several bioinformatics tools and resources are available for predicting a protein's structural and functional relationship. Insights into the proteins' structure and function are important for drug discovery, development, and enhancing the suitability of the recombinant enzymes/proteins for industrial applications. This review compares and discusses various computational tools that provide structural and functional insights into recombinant proteins, including genome mining, sequence alignment, topological arrangement, physicochemical properties, including solubility and stability, site-directed mutagenesis, protein design and engineering, ligand binding interactions through molecular docking, and molecular dynamics simulation. This comparative study explores the utilisation of different computational tools, software, and web servers with their principles, algorithms, and outcomes. This document would be a milestone for the scientists to select suitable computational approaches to plan and improve the outcome for achieving the desired targets.
Indexed as
Identifiers
40924371What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.